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表现为高蛋白、高血清-腹水白蛋白梯度的恶性腹膜间皮瘤。

Malignant Peritoneal Mesothelioma Presenting with High Protein, High Serum-Ascites Albumin Gradient.

作者信息

Kerosky Zachary P, Powell Charleston R, Lindholm Phillip C

机构信息

Internal Medicine, Madigan Army Medical Center, Tacoma, USA.

Internal Medicine, Weed Army Community Hospital, Fort Irwin, USA.

出版信息

Cureus. 2022 Jul 26;14(7):e27286. doi: 10.7759/cureus.27286. eCollection 2022 Jul.

DOI:10.7759/cureus.27286
PMID:36039211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9403261/
Abstract

Mesothelioma is a difficult-to-detect neoplasm that rarely develops in the peritoneum. In patients with unexplained ascites, pleural fluid analysis and ultrasonography is often the first step to achieving a diagnosis. This case report shares a unique presentation in which a patient who presented with unexplained ascites, was initially thought to have cirrhosis but was later found to have malignant peritoneal mesothelioma after cross-sectional imaging and tissue acquisition. This case illustrates the importance of a high clinical index of suspicion for mesothelioma given its variety of clinical presentations, as well as the utility of early cross-sectional imaging in such cases.

摘要

间皮瘤是一种难以检测的肿瘤,很少在腹膜中发生。在患有不明原因腹水的患者中,胸腔积液分析和超声检查通常是实现诊断的第一步。本病例报告分享了一个独特的病例,一名出现不明原因腹水的患者最初被认为患有肝硬化,但后来在进行横断面成像和组织采集后被发现患有恶性腹膜间皮瘤。该病例说明了鉴于间皮瘤临床表现多样,对其保持高度临床怀疑指数的重要性,以及早期横断面成像在此类病例中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ae/9403261/0cbbce0f8fbf/cureus-0014-00000027286-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ae/9403261/0eae33990f73/cureus-0014-00000027286-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ae/9403261/0cbbce0f8fbf/cureus-0014-00000027286-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ae/9403261/0eae33990f73/cureus-0014-00000027286-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ae/9403261/0cbbce0f8fbf/cureus-0014-00000027286-i02.jpg

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本文引用的文献

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A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report.高血清-腹水白蛋白梯度与纵隔纤维肉瘤:一例报告
Middle East J Dig Dis. 2018 Oct;10(4):258-262. doi: 10.15171/mejdd.2018.120. Epub 2018 Sep 7.
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Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline.恶性胸膜间皮瘤的治疗:美国临床肿瘤学会临床实践指南。
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Biochemical analysis of ascitic (peritoneal) fluid: what should we measure?
腹水(腹腔)液的生化分析:我们应该测量什么?
Ann Clin Biochem. 2010 Sep;47(Pt 5):397-407. doi: 10.1258/acb.2010.010048. Epub 2010 Jul 1.
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Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions.未确诊胸腔积液中胸水间皮素的临床影响及可靠性
Am J Respir Crit Care Med. 2009 Sep 1;180(5):437-44. doi: 10.1164/rccm.200811-1729OC. Epub 2009 Mar 19.
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Liver biopsy: the best, not the gold standard.肝活检:是最佳选择,而非金标准。
J Hepatol. 2009 Jan;50(1):1-3. doi: 10.1016/j.jhep.2008.10.014. Epub 2008 Nov 6.
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Diagnosis of malignant ascites. Comparison of ascitic fibronectin, cholesterol, and serum-ascites albumin difference.恶性腹水的诊断。腹水纤维连接蛋白、胆固醇及血清-腹水白蛋白梯度的比较。
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