Bratisl Lek Listy. 2022;123(9):648-652. doi: 10.4149/BLL_2022_104.
Epilepsy is a widespread and mainly severe neurological condition portrayed by recurring spontaneous seizures caused by the brain's abnormal electrical activity. According to new research, inflammation may be both a result and the cause of epileptic seizures. The highest zinc levels in the brain have been found in the hippocampus which is one of the most studied regions of the brain regarding epilepsy. Zinc may have an anti-inflammatory potential as zinc co-factors affect numerous biochemical and physiological reactions. In this study, we evaluated the effects of intraperitoneal zinc administration on seizure activity in murine PTZ model. Rats received either intraperitoneal (IP) zinc sulfate at two different dosages (50-100 mg/kg) or a placebo followed by pentylenetetrazole (IP), a strong seizure-inducing drug. The spike percentages were considerably lower in the PTZ (35 mg/kg) and 50 or 100 mg/kg zinc-treated groups (A3 and A4) than in the PTZ (35 mg/kg) and saline-treated group (A2; p may be used as an adjuvant therapy in combination with other antiepileptic drugs in the future (Tab. 3, Fig. 1, Ref. 27) Keywords: anti-seizure effect of zinc, epilepsy, abnormal electrical activity, antiepileptic drugs, rat model.
癫痫是一种广泛存在且主要严重的神经系统疾病，其特征是由大脑异常电活动引起的反复发作的自发性癫痫发作。根据新的研究，炎症可能既是癫痫发作的结果，也是其原因。大脑中锌含量最高的部位是海马体，海马体是研究癫痫的大脑区域之一。锌可能具有抗炎潜力，因为锌辅因子会影响许多生化和生理反应。在这项研究中，我们评估了腹腔内给予锌对小鼠 PTZ 模型中癫痫发作活动的影响。大鼠接受腹腔内（IP）硫酸锌两种不同剂量（50-100mg/kg）或安慰剂，然后给予戊四氮（IP），一种强烈的致痫药物。在 PTZ（35mg/kg）和 50 或 100mg/kg 锌处理组（A3 和 A4）中，尖峰百分比明显低于 PTZ（35mg/kg）和生理盐水处理组（A2；p<0.05）。在 100mg/kg 锌处理组中，癫痫发作持续时间也明显缩短（p<0.05）。这些结果表明，腹腔内给予锌可能作为辅助治疗与其他抗癫痫药物联合使用（表 3，图 1，参考文献 27）。关键词：锌的抗癫痫作用、癫痫、异常电活动、抗癫痫药物、大鼠模型。
