MR 指纹技术在肝脏组织特征分析中的应用：一项与组织病理学相关性的研究。
MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study.
机构信息
From the Departments of Radiology (S.F., K.S., H.K., I.F., Y.M., K.K., S.A.), Human Pathology (Y.F.), and Gastroenterology (K.I.), Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan; Department of Radiology, University of Tokyo, Tokyo, Japan (S.F., Y.M., O.A.); Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom (G.C., R.M.B., C.P.); Department of MR Clinical Science, Philips Japan, Tokyo, Japan (M.Y.); School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
出版信息
Radiology. 2023 Jan;306(1):150-159. doi: 10.1148/radiol.220736. Epub 2022 Aug 30.
Background Liver MR fingerprinting (MRF) enables simultaneous quantification of T1, T2, T2*, and proton density fat fraction (PDFF) maps in single breath-hold acquisitions. Histopathologic correlation studies are desired for its clinical use. Purpose To compare liver MRF-derived metrics with separate reference quantitative MRI in participants with diffuse liver disease, evaluate scan-rescan repeatability of liver MRF, and validate MRF-derived measurements for histologic grading of liver biopsies. Materials and Methods This prospective study included participants with diffuse liver disease undergoing MRI from July 2021 to January 2022. Participants underwent two-dimensional single-section liver MRF and separate reference quantitative MRI. Linear regression, Bland-Altman plots, and coefficients of variation were used to assess the bias and repeatability of liver MRF measurements. For participants undergoing liver biopsy, the association between mapping and histologic grading was evaluated by using the Spearman correlation coefficient. Results Fifty-six participants (mean age, 59 years ± 15 [SD]; 32 women) were included to compare mapping techniques and 23 participants were evaluated with liver biopsy (mean age, 52.7 years ± 12.7; 14 women). The linearity of MRF with reference measurements in participants with diffuse liver disease ( value) for T1, T2, T2*, and PDFF maps was 0.86, 0.88, 0.54, and 0.99, respectively. The overall coefficients of variation for repeatability in the liver were 3.2%, 5.5%, 7.1%, and 4.6% for T1, T2, T2*, and PDFF maps, respectively. MRF-derived metrics showed high diagnostic performance in differentiating moderate or severe changes from mild or no changes (area under the receiver operating characteristic curve for fibrosis, inflammation, steatosis, and siderosis: 0.62 [95% CI: 0.52, 0.62], 0.92 [95% CI: 0.88, 0.92], 0.97 [95% CI: 0.96, 0.97], and 0.74 [95% CI: 0.57, 0.74], respectively). Conclusion Liver MR fingerprinting provided repeatable T1, T2, T2*, and proton density fat fraction maps in high agreement with reference quantitative mapping and may correlate with pathologic grades in participants with diffuse liver disease. © RSNA, 2022
背景 肝脏磁共振指纹技术（MRF）可在单次屏气采集时同时定量 T1、T2、T2* 和质子密度脂肪分数（PDFF）图。为了将其应用于临床，需要进行与组织病理学的相关性研究。目的 本研究旨在比较弥漫性肝病患者中肝脏 MRF 衍生指标与单独参考定量 MRI 的相关性，评估肝脏 MRF 扫描-再扫描的可重复性，并验证 MRF 衍生测量值与肝活检组织学分级的相关性。材料与方法 本前瞻性研究纳入了 2021 年 7 月至 2022 年 1 月期间接受 MRI 检查的弥漫性肝病患者。患者接受二维单节段肝脏 MRF 和单独的参考定量 MRI 检查。采用线性回归、Bland-Altman 图和变异系数评估肝脏 MRF 测量值的偏倚和可重复性。对于接受肝活检的患者，采用 Spearman 相关系数评估图谱与组织学分级的相关性。结果 本研究共纳入 56 例患者（平均年龄，59 岁±15[标准差]；32 例女性）用于比较图谱技术，纳入 23 例患者进行肝活检（平均年龄，52.7 岁±12.7；14 例女性）。弥漫性肝病患者的 MRF 与参考测量值的线性关系（r 值）分别为 0.86、0.88、0.54 和 0.99，对应 T1、T2、T2* 和 PDFF 图。肝脏重复扫描的总体变异系数分别为 3.2%、5.5%、7.1%和 4.6%，对应 T1、T2、T2* 和 PDFF 图。MRF 衍生指标在区分中度或重度改变与轻度或无改变方面具有较高的诊断效能（纤维化、炎症、脂肪变性和铁沉积的受试者工作特征曲线下面积：0.62[95%CI：0.52，0.62]、0.92[95%CI：0.88，0.92]、0.97[95%CI：0.96，0.97]和 0.74[95%CI：0.57，0.74]）。结论 肝脏磁共振指纹技术提供了具有高度一致性的 T1、T2、T2* 和质子密度脂肪分数图谱，且可重复性较好，与弥漫性肝病患者的病理分级相关。 © 2022 RSNA
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