Aguado Casanova Víctor, Ventas Beatriz, Arroyo Palomo Jaime, Huelin Alcubierre Fernando J, Villalobos Sánchez Lourdes, Revenga Martínez Marcelino, Gonzalez-Lopez Julio J
Ophthalmology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Carretera de Colmenar Km 9,100, 28034, Madrid, Spain.
Rheumatology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
Int Ophthalmol. 2023 Mar;43(3):771-777. doi: 10.1007/s10792-022-02477-1. Epub 2022 Aug 30.
To describe the epidemiology and clinical characteristics of psoriatic arthritis (PsA) related uveitis in Madrid, Spain.
A case series nested in a retrospective single-center cohort of 494 patients with PsA was performed. Patients older than 18 years old whit a clinical diagnosis PsA-related uveitis who attended the Ramon y Cajal University Hospital in Madrid, Spain, between 1st January 2017 and 31st December 2019 were included in the study. Epidemiological and clinical data were retrieved from the electronic medical records.
Thirteen cases of psoriatic arthritis-related uveitis (6 men and 7 women) were included. PsA-related uveitis showed an incidence of 0.05 cases per 100,000 persons/year (CI95 0.00-0.35), and a prevalence of 2.19 cases per 100,000 persons (CI95 1.24-3.79). The prevalence of active uveitis in the cohort of PsA patients was 2.6%. The first episode of uveitis (mean age of 48.15 ± 15.41 years) was anterior and unilateral in 92.31% of the cases. Most of the patients had a recurrent course (69.2%) with 0.92 flare-ups per patient/year (CI95 0.85-0.96). The uveitis preceded the diagnosis of psoriatic arthritis in 62.5% of the patients. In patients with PsA-related uveitis, HLA-B27 was present in 23.1%, HLA-Cw6 in 7.7%.
Uveitis is a PsA manifestation that affects roughly 1 in 37 PsA patients, and that may precede the articular symptoms. It generally presents as a unilateral acute anterior uveitis and has a recurrent course. The most frequent observed complications are elevated intraocular pressure and cataracts.
描述西班牙马德里银屑病关节炎（PsA）相关葡萄膜炎的流行病学和临床特征。
在一项对494例PsA患者的回顾性单中心队列研究中进行病例系列分析。纳入2017年1月1日至2019年12月31日期间在西班牙马德里拉蒙·伊·卡哈尔大学医院就诊、年龄大于18岁且临床诊断为PsA相关葡萄膜炎的患者。从电子病历中检索流行病学和临床数据。
纳入13例银屑病关节炎相关葡萄膜炎患者（6例男性和7例女性）。PsA相关葡萄膜炎的发病率为每10万人年0.05例（95%CI 0.00 - 0.35），患病率为每10万人2.19例（95%CI 1.24 - 3.79）。PsA患者队列中活动性葡萄膜炎的患病率为2.6%。葡萄膜炎首发时（平均年龄48.15±15.41岁），92.31%的病例为前部且单侧。大多数患者病程呈复发型（69.2%），每位患者每年发作0.92次（95%CI 0.85 - 0.96）。62.5%的患者葡萄膜炎先于银屑病关节炎诊断出现。在PsA相关葡萄膜炎患者中，HLA - B27阳性率为23.1%，HLA - Cw6阳性率为7.7%。
葡萄膜炎是PsA的一种表现形式，约每37例PsA患者中有1例受影响，且可能先于关节症状出现。通常表现为单侧急性前部葡萄膜炎，病程呈复发型。最常见的并发症是眼压升高和白内障。
