内源性循环雄激素水平与显微镜下结肠炎风险无关。

Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis.

作者信息

Tracy Michaela S, Challa Prasanna K, Canha Lauren, Burke Kristin, Ananthakrishnan Ashwin N, Lopes Emily W, Richter James M, Chan Andrew T, Khalili Hamed

机构信息

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.

出版信息

Dig Dis Sci. 2023 Feb;68(2):571-579. doi: 10.1007/s10620-022-07678-3. Epub 2022 Aug 30.

DOI:10.1007/s10620-022-07678-3

PMID:36040554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11645841/

Abstract

BACKGROUND

Microscopic colitis is a chronic inflammatory disease that most commonly affects post-menopausal women. Exogenous hormone use has recently been linked with increased risk of microscopic colitis. Yet, it is unclear whether levels of endogenous sex hormones are also associated with risk of microscopic colitis.

AIM

To evaluate the association between prediagnostic plasma androgens and subsequent risk of microscopic colitis.

METHODS

We conducted a case-control study nested within prospective cohort studies of the Nurses' Health Study (NHS) and NHSII. Cases of microscopic colitis were each matched to two controls according to age, cohort, menopause status, fasting status, and season of plasma collection. Prediagnosis plasma levels of androgens including dehydroepiandrosterone sulfate, testosterone, and sex hormone-binding globulin were measured. We examined the association of each analyte with risk of microscopic colitis using conditional logistic regression models.

RESULTS

Our study included 96 cases of microscopic colitis matched to 190 controls. Plasma levels of testosterone were not associated with risk of microscopic colitis (P = 0.70). Compared to participants in the lowest quartile of plasma testosterone levels, the aOR of microscopic colitis for women in the highest quartile was 0.88, 95% CI 0.45-1.71. Similarly, we did not observe an association between dehydroepiandrosterone sulfate and sex hormone-binding globulin and risk of microscopic colitis (all P > 0.52).

CONCLUSION

Among women, prediagnostic circulating levels of testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin are not associated with risk of microscopic colitis.

摘要

背景

显微镜下结肠炎是一种慢性炎症性疾病，最常影响绝经后女性。近期研究发现，外源性激素的使用与显微镜下结肠炎风险增加有关。然而，内源性性激素水平是否也与显微镜下结肠炎风险相关尚不清楚。

目的

评估诊断前血浆雄激素水平与随后患显微镜下结肠炎风险之间的关联。

方法

我们在护士健康研究（NHS）和NHSII的前瞻性队列研究中进行了一项病例对照研究。根据年龄、队列、绝经状态、空腹状态和血浆采集季节，将显微镜下结肠炎病例与两名对照进行匹配。测量诊断前血浆中硫酸脱氢表雄酮、睾酮和性激素结合球蛋白等雄激素水平。我们使用条件逻辑回归模型检验每种分析物与显微镜下结肠炎风险的关联。

结果

我们的研究纳入了96例显微镜下结肠炎病例和190名对照。睾酮血浆水平与显微镜下结肠炎风险无关（P = 0.70）。与血浆睾酮水平处于最低四分位数的参与者相比，血浆睾酮水平处于最高四分位数的女性患显微镜下结肠炎的调整后比值比为0.88，95%置信区间为0.45 - 1.71。同样，我们未观察到硫酸脱氢表雄酮和性激素结合球蛋白与显微镜下结肠炎风险之间存在关联（所有P > 0.52）。