Yang Yaqi, Liu Shuai, Gan Jinghuan, Zhu Han, Du Xiaoshan, Chen Zhichao, Ma Lingyun, Meng Qingbo, Yang Fan, Chen Hui, Ji Yong
Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Int J Geriatr Psychiatry. 2022 Sep;37(9). doi: 10.1002/gps.5806.
In the present study, the association between Hemoglobin (HGB) level and cognitive profile was investigated and whether it affected the dementia risk in older adults.
A cross-sectional population-based survey that included 3519 individuals ≥65 years of age was conducted in 2019. Basic demographic characteristics were collected. The neuropsychological assessments and blood tests were administered to evaluate cognition and HGB level. Generalized additive models were used to analyze the non-linear association between HGB levels and cognitive function. Logistics regression models were utilized to analyze the associations between HGB level and dementia risk.
Overall, 459 (12.7%) participants were diagnosed with dementia and there were more females (54.7%) than males (45.3%). The number of subjects with anemia (3%) or hyperhemoglobinemia (5.2%) was higher than participants with normal HGB level. A visual representation of the relationship between HGB level and Mini-Mental State Examination (MMSE) score showed an inverted U-curve, which is more evident in female. Logistics regression models showed that anemia (odds ratio, OR = 1.826, 95% confidence interval, CI: 1.166-2.860, p < 0.01), but not hyperhemoglobinemia, significantly increased the risk of dementia. These trends were not the same for males and females. An abnormal HGB level had greater effects in females, resulting in higher risk of dementia for females with anemia or hyperhemoglobinemia than subjects with normal HGB level including males.
Both low and high HGB levels can lead to cognitive decline in the incidence of dementia, indicating an inverted U-shaped curve association may exist between HGB level and global cognitive profile.
在本研究中，调查了血红蛋白（HGB）水平与认知状况之间的关联，以及其是否会影响老年人患痴呆症的风险。
2019年进行了一项基于人群的横断面调查，纳入了3519名年龄≥65岁的个体。收集了基本人口统计学特征。进行了神经心理学评估和血液检查以评估认知和HGB水平。使用广义相加模型分析HGB水平与认知功能之间的非线性关联。采用逻辑回归模型分析HGB水平与痴呆风险之间的关联。
总体而言，459名（12.7%）参与者被诊断患有痴呆症，女性（54.7%）多于男性（45.3%）。贫血（3%）或高血红蛋白血症（5.2%）患者的数量高于HGB水平正常的参与者。HGB水平与简易精神状态检查表（MMSE）评分之间关系的直观呈现显示为倒U形曲线，在女性中更为明显。逻辑回归模型显示，贫血（比值比，OR = 1.826，95%置信区间，CI：1.166 - 2.860，p < 0.01）而非高血红蛋白血症显著增加了痴呆风险。这些趋势在男性和女性中并不相同。异常HGB水平对女性的影响更大，导致贫血或高血红蛋白血症的女性患痴呆症的风险高于包括男性在内的HGB水平正常的受试者。
低HGB水平和高HGB水平均可导致痴呆症发病率的认知下降，表明HGB水平与整体认知状况之间可能存在倒U形曲线关联。
