Clinical Research Development Center, The Persian Gulf Martyrs, Bushehr University of Medical Sciences, Bushehr, Iran.
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
BMC Geriatr. 2021 May 24;21(1):329. doi: 10.1186/s12877-021-02285-9.
The present study aimed to investigate the relation between anemia and hemoglobin (Hgb) concentration, physical performance, and cognitive function in a large sample of Iranian elderly population.
Data were collected from Bushehr elderly health (BEH) program. A total of 3000 persons aged ≥60 years were selected through multistage random sampling. Hemoglobin values lower than 12 and 13 g/dL were considered as anemia for women and men, respectively. The cognitive function was measured using the Mini-cog test and Category fluency test (CFT), and the physical function was measured using handgrip strength (muscle strength), Relative handgrip strength (RHGS), and 4.57-m usual gait speed. Univariate and adjusted multivariate logistic regression and linear regression with Stata MP (version 15) were run, and a p-value of < 0.05 was used as statistically significant for all analyses.
Among participants, 7.43% were anemic, and 115 (51.57%) simultaneously had anemia and cognitive disorder. There were significant associations between red blood cell count (RBC), hemoglobin (Hgb), platelet count (PLT), and hematocrit percentage (HCT) with cognitive impairment. Additionally, Hgb concentration was significantly associated with all physical measures (Mean handgrip, Relative handgrip, and usual gait speed) and late recall (mini-cog) among the whole participants. This association remained statistically significant after considering multi-cofounders. In contrast, after stratifying the participants by gender, the association between Hgb concentration and usual gait speed was decreased in both men and women; moreover, Hgb association with cognitive measures (category fluency test and late recall) was no longer significant (all p-values > 0.05).
There was a cross-sectional and significant association between anemia and functional variables (e.g., Relative and mean handgrip) in Iranian elderly population, whereas Semantic memory, Late recall, and walking were more affected by gender.
本研究旨在调查伊朗老年人群体中大量样本中贫血与血红蛋白（Hgb）浓度、身体表现和认知功能之间的关系。
数据来自布什尔老年健康（BEH）计划。通过多阶段随机抽样选择了 3000 名年龄≥60 岁的人。女性和男性的血红蛋白值低于 12 和 13 g/dL 分别被认为是贫血。认知功能使用 Mini-cog 测试和类别流畅性测试（CFT）进行测量，身体功能使用握力（肌肉力量）、相对握力（RHGS）和 4.57 米通常的步行速度进行测量。使用 Stata MP（版本 15）进行单变量和调整后的多变量逻辑回归和线性回归，所有分析的统计显著性 p 值均设为<0.05。
参与者中，7.43%患有贫血，115 人（51.57%）同时患有贫血和认知障碍。红细胞计数（RBC）、血红蛋白（Hgb）、血小板计数（PLT）和血细胞比容（HCT）与认知障碍之间存在显著关联。此外，在所有参与者中，Hgb 浓度与所有身体测量值（平均握力、相对握力和通常的步行速度）和 Mini-cog 的晚期回忆均显著相关。在考虑多因素后，这种关联仍然具有统计学意义。相比之下，在按性别对参与者进行分层后，男性和女性的 Hgb 浓度与通常的步行速度之间的关联减弱；此外，Hgb 与认知测量值（类别流畅性测试和晚期回忆）之间的关联不再显著（所有 p 值均>0.05）。
在伊朗老年人群体中，贫血与功能变量（如相对和平均握力）之间存在横断面和显著关联，而语义记忆、晚期回忆和行走更多地受到性别的影响。
