College of Medicine, University of Illinois Chicago, Chicago, Illinois, United States of America.
School of Public Health, University of Illinois Chicago, Chicago, Illinois, United States of America.
PLoS One. 2022 Aug 30;17(8):e0269964. doi: 10.1371/journal.pone.0269964. eCollection 2022.
The objectives of the HOLISTIC Cohort Study are to establish a prospective cohort study covering a period of three years that characterizes the health of students within and across health professional education programs at the University of Illinois Chicago (UIC) during the coronavirus disease 2019 (COVID-19) pandemic, implement an interprofessional student research team, and generate a meaningful dataset that is used to inform initiatives that improve student health. This report describes the protocol of the HOLISTIC Cohort Study, including survey development, recruitment strategy, and data management and analysis.
An interprofessional student research team has been organized with the goal of providing continuous assessment of study design and implementation across the seven health science colleges (applied health sciences, dentistry, medicine, nursing, pharmacy, public health, and social work) at the University of Illinois Chicago in Chicago, IL. To be eligible to participate in the HOLISTIC Cohort Study, students are required to be 1) age 18 years or older; 2) enrolled full- or part-time in one or more of UIC's seven health science colleges; and 3) enrolled in a program that prepares its graduates to enter a healthcare profession. The study protocol includes a series of three recruitment waves (Spring 2021 [April 14, 2021, to May 5, 2021; completed], Spring 2022, Spring 2023). In the first recruitment wave, eligible students were sent an invitation via electronic mail (e-mail) to complete an online survey. The online survey was based on the U.S. Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System 2019 survey and the 2014 World Health Organization Report of the Strategic Advisory Group of Experts Working Group Vaccine Hesitancy Scale. Electronic informed consent and study data are collected and managed using Research Electronic Data Capture (REDCap) tools. This study utilizes convenience sampling from all seven health science colleges at UIC with a target recruitment total of 2,000 participants.
A total of 555 students across all seven health science colleges (10.8% of 5,118 students who were invited; 27.6% of target sample size) enrolled in the cohort during the first recruitment wave. The pilot data establishes the feasibility of the study during the COVID-19 pandemic. Adaptations to overcome barriers to study implementation, including the use of remote, rather than in-person, study meetings, staff training, and participant recruitment are discussed. For the second and third waves of recruitment, the student research team will seek institutional review board (IRB) approval to implement additional enrollment strategies that are tailored to each health science college, such as online newsletters, virtual townhalls, flyers on bulletin boards near classrooms tailored to each health science college.
HOLISTIC 队列研究的目的是建立一个为期三年的前瞻性队列研究，该研究将在 2019 年冠状病毒病 (COVID-19) 大流行期间，在伊利诺伊大学芝加哥分校 (UIC) 的健康专业教育项目内和跨项目，对学生的健康状况进行特征描述，实施一个跨专业学生研究团队，并生成一个有意义的数据集，用于为改善学生健康的计划提供信息。本报告介绍了 HOLISTIC 队列研究的方案，包括调查的制定、招募策略以及数据管理和分析。
已经组建了一个跨专业的学生研究团队，目标是为伊利诺伊大学芝加哥分校七个健康科学学院（应用健康科学、牙科学、医学、护理、药学、公共卫生和社会工作）提供持续评估研究设计和实施的情况。要符合参与 HOLISTIC 队列研究的条件，学生必须满足以下条件：1) 年龄在 18 岁或以上；2) 全日制或非全日制就读于 UIC 的七个健康科学学院之一或多个学院；3) 入读的项目是为培养未来从事医疗保健行业的学生而设立的。该研究方案包括三个招募阶段（2021 年春季[2021 年 4 月 14 日至 5 月 5 日；已完成]、2022 年春季、2023 年春季）。在第一阶段招募中，符合条件的学生通过电子邮件收到完成在线调查的邀请。在线调查基于美国疾病控制与预防中心的行为风险因素监测系统 2019 年调查和 2014 年世界卫生组织专家工作组报告的疫苗犹豫量表。电子知情同意书和研究数据使用 Research Electronic Data Capture (REDCap) 工具进行收集和管理。本研究利用 UIC 所有七个健康科学学院的便利抽样，目标招募总人数为 2000 人。
在第一阶段招募中，来自所有七个健康科学学院的 555 名学生（邀请的 5118 名学生中的 10.8%；目标样本量的 27.6%）入组该队列。试点数据确立了在 COVID-19 大流行期间进行该研究的可行性。讨论了克服研究实施障碍的适应措施，包括使用远程而非面对面的研究会议、员工培训和参与者招募。在第二和第三阶段的招募中，学生研究团队将寻求机构审查委员会 (IRB) 的批准，以实施针对每个健康科学学院的额外招募策略，例如针对每个健康科学学院的在线新闻通讯、虚拟市政厅、贴在教室附近布告板上的传单。
