Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Int Immunopharmacol. 2022 Nov;112:109188. doi: 10.1016/j.intimp.2022.109188. Epub 2022 Aug 27.
Long non-coding RNAs that regulate function of regulatory T cells can affect pathoetiology of autoimmune disorders, such as inflammatory demyelinating polyneuropathies. In the current case-control study, we compared expression of four of these lncRNAs, namely FLICR, NEST, RMRP and TH2-LCR between patients with inflammatory demyelinating polyneuropathies and healthy subjects. Expressions of RMRP, NEST and FLICR were higher in total patients compared with controls. However, there was no significant difference in their expressions between acute and chronic demyelinating polyneuropathies. In addition, interaction of gender and disease factors had significant effect on expression levels of RMRP and TH2-LCR genes in subgroups. RMRR was superior to other lncRNAs in terms of AUC, sensitivity and specificity values in total patients and both subgroups of patients. This lncRNA could separate total patients, female patients and male patients from corresponding controls with AUC values (±SD) of 0.9 ± 0.03, 0.86 ± 0.07 and 0.93 ± 0.03, respectively. FLICR ranked second in this regard, since it could separate total patients, female patients and male patients from corresponding controls with AUC values (±SD) of 0.81 ± 0.03, 0.72 ± 0.07 and 0.87 ± 0.04, respectively. Therefore, our study provides evidence for participation of regulatory T cells-related lncRNAs in the pathoetiology of inflammatory demyelinating polyneuropathies.
长非编码 RNA 可以调节调节性 T 细胞的功能，从而影响自身免疫性疾病的病理生理学，如炎症性脱髓鞘性多发性神经病。在当前的病例对照研究中，我们比较了 4 种长非编码 RNA（FLICR、NEST、RMRP 和 TH2-LCR）在炎症性脱髓鞘性多发性神经病患者和健康对照者中的表达。与对照组相比，总患者的 RMRP、NEST 和 FLICR 表达较高。然而，急性和慢性脱髓鞘性多发性神经病之间它们的表达没有显著差异。此外，性别和疾病因素的相互作用对亚组中 RMRP 和 TH2-LCR 基因的表达水平有显著影响。RMRR 在总患者和患者的两个亚组中，在 AUC、敏感性和特异性方面均优于其他 lncRNAs。该 lncRNA 可以将总患者、女性患者和男性患者与相应的对照组区分开来，AUC 值（±SD）分别为 0.9±0.03、0.86±0.07 和 0.93±0.03。FLICR 在这方面排名第二，因为它可以将总患者、女性患者和男性患者与相应的对照组区分开来，AUC 值（±SD）分别为 0.81±0.03、0.72±0.07 和 0.87±0.04。因此，我们的研究为调节性 T 细胞相关 lncRNA 参与炎症性脱髓鞘性多发性神经病的病理生理学提供了证据。
