ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Hearing Medicine Research (Fudan University), Shanghai, 200031, China.
Department of Otorhinolaryngology Head and Neck Surgery, XinHua Hospital, Shanghai Jiaotong University, Shanghai, 200092, China.
Sleep Med. 2022 Dec;100:112-119. doi: 10.1016/j.sleep.2022.08.002. Epub 2022 Aug 11.
To identify the typical pattern of changes of vestibular-evoked myogenic potentials (VEMPs) and explore the relationship between VEMPs and the anthropometry factors in patients with obstructive sleep apnea (OSA).
Patients diagnosed as OSA after overnight polysomnography (PSG) tests were enrolled as the study group. Healthy volunteers were recruited as the control group. Anthropometry data of the body shape and VEMPs results were collected completely. The correlation analysis was conducted among those parameters.
Forty-nine patients with OSA who were diagnosed in the Therapy Center of Sleep-disordered Breathing in our hospital and sex- and age-matched healthy controls as well. Significant changes in ocular and cervical VEMPs (oVEMP and cVEMP) in the study group were observed, which were reduced response rates, elevated thresholds, decreased amplitudes, and prolonged first wave latencies. In oVEMP, the first wave (n1) latency was significantly correlated with weight, body mass index (BMI), neck circumference, waist circumference, hip circumference, and apnea hypopnea index (AHI). In a tentative application, combined use of BMI and oVEMP n1 latency increased the detection rate during OSA screening prior to PSG.
OSA can negatively affect function of otolithic organs and their pathways. The first wave latency of the VEMPs waveform may be another important parameter to define peripheral nervous system lesions caused by systemic diseases as OSA.
识别前庭诱发肌源性电位（VEMPs）变化的典型模式，并探讨 VEMPs 与阻塞性睡眠呼吸暂停（OSA）患者人体测量学因素之间的关系。
将经整夜多导睡眠图（PSG）检查诊断为 OSA 的患者纳入研究组，招募健康志愿者作为对照组。完整收集人体形态学的人体测量学数据和 VEMPs 结果。对这些参数进行相关性分析。
研究组共纳入 49 例 OSA 患者和性别、年龄匹配的健康对照组。研究组观察到眼震和颈肌 VEMPs（oVEMP 和 cVEMP）的明显变化，包括反应率降低、阈值升高、幅度降低和第一波潜伏期延长。在 oVEMP 中，第一波（n1）潜伏期与体重、体重指数（BMI）、颈围、腰围、臀围和呼吸暂停低通气指数（AHI）显著相关。在初步应用中，BMI 和 oVEMP n1 潜伏期的联合使用提高了 PSG 前 OSA 筛查的检测率。
OSA 可对耳石器官及其通路的功能产生负面影响。VEMPs 波形的第一波潜伏期可能是另一个定义 OSA 等全身性疾病引起的周围神经系统病变的重要参数。
