Iagovdik N Z, Fedorova T A, Detinkin O N
Vopr Med Khim. 1987 Mar-Apr;33(2):62-4.
Two forms of nucleoprotein complex alpha and beta were found in human keratinocytes by means of nucleoprotein celite chromatography. They were not observed any principal differences between distribution of chromatin various forms in impaired and normal skin of the patients with psoriasis as well as in skin of healthy persons. Only slight differences were detected in the ratio of radioactive DNA in alpha and beta forms of chromatin from impaired and normal keratinocytes, while tightly-bound DNA was increased in psoriasis. In psoriasis acceleration of keratinocyte cell cycle but not an increase in proliferating cells pool appear to occur.
通过核蛋白硅藻土色谱法在人角质形成细胞中发现了两种形式的核蛋白复合物α和β。在银屑病患者受损皮肤和正常皮肤以及健康人的皮肤中，未观察到染色质各种形式的分布存在任何主要差异。仅在受损和正常角质形成细胞的染色质α和β形式中放射性DNA的比例检测到轻微差异，而银屑病中紧密结合的DNA增加。在银屑病中，角质形成细胞周期加速，但增殖细胞池并未增加。
