Ryzhenkov V E, Prokop'ev A A, Nersisian G G, Kameneva I Iu, Shavva A G
Vopr Med Khim. 1987 Mar-Apr;33(2):65-8.
Racemic 16,16-dimethyl-D-homo-8-isoestrone methyl ester (substance 1) was shown to decrease the content of cholesterol in blood serum and liver tissue of animals with induced hyperlipidemia (rats, guinea pigs, rabbits) as well as to decrease the rate of atherosclerotic impairments in rabbit aorta. As distinct from usual estrogen, the substance I did not cause hypertriglyceridemia but normalized triglycerides in blood and liver tissue. Substance I exhibited low toxic effects.
外消旋16,16 - 二甲基 - D - 高 - 8 - 异雌酮甲酯（物质1）已显示可降低诱导性高脂血症动物（大鼠、豚鼠、家兔）血清和肝脏组织中的胆固醇含量，还可降低家兔主动脉中动脉粥样硬化损伤的发生率。与普通雌激素不同，物质1不会引起高甘油三酯血症，反而能使血液和肝脏组织中的甘油三酯水平恢复正常。物质1显示出低毒性作用。
