Kameneva I Iu, Shavva A G, Lozovskiĭ V G, Ryzhenkov V E
Biull Eksp Biol Med. 1992 Jul;114(8):148-50.
Ovariectomy of rats resulted in biphasic increase of the blood plasma cholesterol (on days 42-54, 70), the alteration of lipoprotein spectrum. The administration to ovariectomized rats of methyl ether 6-oxy-D-homo-8-isoestrone in a dose of 0.01 mg/kg brought about lowering of serum cholesterol and normalization of lipoproteins spectrum. The above trends were not observed after introduction of 0.01 mg/kg estradiol.
大鼠卵巢切除导致血浆胆固醇双相升高（在第42 - 54天、70天），脂蛋白谱发生改变。给卵巢切除的大鼠腹腔注射剂量为0.01mg/kg的6-氧代-D-高-8-异雌酮甲醚，可使血清胆固醇降低，脂蛋白谱恢复正常。注射0.01mg/kg雌二醇后未观察到上述趋势。
