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[兔、豚鼠和大鼠离体灌流肝脏各种生化和生理参数的比较研究]

[Comparative study of various biochemical and physiological parameters of isolated perfused liver of rabbits, guinea pigs and rats].

作者信息

Kozlov S A, Kiselev E N, Zinov'ev Iu V

出版信息

Vopr Med Khim. 1987 Mar-Apr;33(2):68-70.

PMID:3604145
Abstract

As shown in 24 experiments using 60-min normothermic perfusion of isolated liver tissue from rabbit, guinea pig and rat, the tissues from guinea pig and rat proved to be more resistant to the impairing effect of hypoxia; besides, there was the higher rate of main energy producing processes--tissue respiration and glycolysis. This suggests that resistance of isolated liver tissue to the effect of hypoxia, involved in the processes of tissue damage in storage, depended directly on intensity of energetic reactions in the tissue.

摘要

在对兔、豚鼠和大鼠分离的肝组织进行60分钟常温灌注的24项实验中发现,豚鼠和大鼠的组织对缺氧损伤作用的耐受性更强;此外,主要能量产生过程——组织呼吸和糖酵解的速率更高。这表明,分离的肝组织对缺氧作用的耐受性,而缺氧参与了储存过程中的组织损伤过程,直接取决于组织中能量反应的强度。

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