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脑静脉窦血栓形成继发于圆斑蝰(Daboia russelii)蛇毒中毒:病例报告及文献复习。

Cerebral venous sinus thrombosis following Russell's viper (Daboia russelii) envenomation: A case report and review of the literature.

机构信息

Department of General Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.

Section of Clinical Neurophysiology, Department of Neurology, University Hospital "La Paz", Madrid, Spain.

出版信息

Toxicon. 2022 Oct 30;218:8-12. doi: 10.1016/j.toxicon.2022.08.014. Epub 2022 Aug 27.

Abstract

Snakebite is a life-threatening and often-neglected public health hazard with high chronic disability and mortality, mainly faced by rural communities in the tropics/subtropics. Stroke and neuromuscular paralysis are the most severe neurological complications. However, cerebral venous sinus thrombosis has rarely been reported among cerebrovascular complications. We report a previously healthy middle-aged Indian woman who developed cerebral venous sinus thrombosis preceded by features of disseminated bleeding diathesis following Russell's viper bite. The cerebral venous sinus thrombosis was diagnosed by magnetic resonance imaging. The patient responded well to treatment with antivenom and subcutaneous enoxaparin and had no demonstrable neurological deficits at three months of follow-up.

摘要

蛇咬伤是一种危及生命且常被忽视的公共卫生危害,主要发生在热带/亚热带的农村社区,具有较高的慢性残疾和死亡率。中风和神经肌肉瘫痪是最严重的神经并发症。然而,在脑血管并发症中,脑静脉窦血栓形成很少见。我们报告了一例先前健康的中年印度妇女,她在被罗素蝰蛇咬伤后出现弥散性出血倾向的特征,随后发生脑静脉窦血栓形成。脑静脉窦血栓形成通过磁共振成像诊断。患者对蛇毒血清和皮下依诺肝素治疗反应良好,在随访 3 个月时没有明显的神经功能缺损。

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