Daniels G L, Levene C, Berrebi A, Schechter Y, Moulds M, Sela R, Poole J, Lacey P, Atkins C J
Medical Research Council Blood Group Unit, London, UK.
Vox Sang. 1988;55(3):161-4. doi: 10.1111/j.1423-0410.1988.tb05085.x.
Three examples of an antibody were found to be detecting a red cell polymorphism probably identical to MER2. The antibodies were made by Jews originating from India and living in Israel. Two of them were sibs and the third was unrelated. All 3 had kidney disease requiring renal dialysis and regular blood transfusion. In 2 cases the antibodies were detected before dialysis was started and before the patients had been transfused. The human antibodies reacted with red cells of 90% of Israeli blood donors tested. In tests on selected blood donors, 82 English and 56 Israeli, one of the human antibodies gave almost identical reactions to those given by monoclonal anti-MER2. Anomalous reactions were probably due to anti-Bga. Two of the human antibodies completely blocked, and one partially blocked, the reaction of monoclonal anti-MER2 with MER2+ red cells.
发现有三例抗体可检测到一种可能与MER2相同的红细胞多态性。这些抗体由来自印度且居住在以色列的犹太人产生。其中两例是同胞，第三例无血缘关系。三人都患有需要肾透析和定期输血的肾脏疾病。在两例中，抗体是在开始透析之前以及患者输血之前检测到的。这些人源抗体与90%接受检测的以色列献血者的红细胞发生反应。在对选定的82名英国献血者和56名以色列献血者进行的检测中，其中一种人源抗体产生的反应与单克隆抗MER2几乎相同。异常反应可能是由于抗Bga所致。其中两种人源抗体完全阻断，一种部分阻断，单克隆抗MER2与MER2+红细胞的反应。
