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人型支原体:急性中耳炎合并面神经麻痹的罕见病例

Mycoplasma Hominis: A Rare Case of Acute Otitis Media and Facial Nerve Paralysis.

作者信息

Sadhar Birkaran, Ko-Keeney Ellen, Fornelli Rick, Lipman Sidney

机构信息

Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

Department of Otolaryngology, University of Pittsburgh Medical Center Hamot, Erie, PA, USA.

出版信息

Ear Nose Throat J. 2025 Mar;104(1_suppl):136S-138S. doi: 10.1177/01455613221113814. Epub 2022 Aug 30.

DOI:10.1177/01455613221113814
PMID:36041826
Abstract

Facial paralysis secondary to acute otitis media (AOM) is rare in the post-antibiotic era. In immunosuppressed patients, atypical bacteria are more commonly encountered as the cause. , normally found in the genitourinary tract, uncommonly causes extragenital infection. We report a case of AOM secondary to , complicated by facial paralysis in an immunosuppressed patient. A 24-year-old male with multiple sclerosis, on rituximab, presented to the emergency department with otalgia and facial paralysis. He was diagnosed with Bell's palsy and subsequently referred to the otolaryngology service. Examination revealed right facial paralysis and purulent otorrhea. Computed tomography (CT) of the temporal bone showed right tympanic and mastoid opacification. The patient was admitted and started on IV ampicillin/sulbactam, IV dexamethasone, and ciprofloxacin/dexamethasone otic drops. Debridement and examination under anesthesia revealed a right tympanic membrane perforation and granulation tissue. Biopsy and cultures were obtained. Final cultures were positive for . Facial paralysis is an uncommon complication of AOM but typically resolves once appropriate antibiotic therapy is regimented. Because can be missed on routine culture, clinicians should consider workup for atypical organisms in settings of immunosuppression so appropriate antibiotic therapy can be initiated.

摘要

在抗生素时代后,急性中耳炎(AOM)继发的面神经麻痹较为罕见。在免疫抑制患者中,非典型细菌更常作为病因被发现。通常存在于泌尿生殖道的[具体细菌名称未给出]很少引起生殖道外感染。我们报告一例免疫抑制患者发生的[具体细菌名称未给出]所致AOM继发面神经麻痹的病例。一名24岁患有多发性硬化症且正在接受利妥昔单抗治疗的男性因耳痛和面神经麻痹就诊于急诊科。他最初被诊断为贝尔麻痹,随后转诊至耳鼻喉科。检查发现右侧面神经麻痹和脓性耳漏。颞骨计算机断层扫描(CT)显示右侧鼓膜和乳突混浊。患者入院后开始静脉滴注氨苄西林/舒巴坦、静脉滴注地塞米松以及使用环丙沙星/地塞米松耳滴剂。在麻醉下进行清创和检查发现右侧鼓膜穿孔和肉芽组织。进行了活检和培养。最终培养结果显示[具体细菌名称未给出]呈阳性。面神经麻痹是AOM的一种罕见并发症,但一旦进行适当的抗生素治疗通常会痊愈。由于[具体细菌名称未给出]在常规培养中可能被漏检,临床医生在免疫抑制情况下应考虑对非典型病原体进行检查,以便能够开始适当的抗生素治疗。

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引用本文的文献

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Infect Dis Ther. 2024 Oct;13(10):2179-2193. doi: 10.1007/s40121-024-01035-9. Epub 2024 Sep 4.
2
Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage.食敌:支原体逃避中性粒细胞胞外陷阱(NETs)的策略促进细菌核苷酸摄取和炎症损伤。
Int J Mol Sci. 2022 Nov 30;23(23):15030. doi: 10.3390/ijms232315030.