Parghane Rahul V, Basu Sandip
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Homi Bhabha National Institute, Mumbai, India.
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Homi Bhabha National Institute, Mumbai, India
J Nucl Med Technol. 2023 Sep;51(3):261-262. doi: 10.2967/jnmt.122.264014. Epub 2022 Aug 30.
Prostate-specific membrane antigen (PSMA) expression has been observed in the neovasculature of various malignancies. We present a case of metastatic renal cell carcinoma (RCC) with comparative F-FDG PET/CT and Ga-PSMA-11 imaging in which FDG PET/CT failed to detect metastatic thyroid disease and showed less F-FDG-concentrating lesions at other sites, whereas Ga-PSMA-11 PET/CT identified metastatic thyroid disease and demonstrated intensely Ga-PSMA-11-expressing distant metastatic lesions. Ga-PSMA-11 PET/CT may be considered a potentially useful imaging technique in RCC to detect metastasis and to guide the choice of specific treatments, such as PSMA-based radionuclide therapy in patients with recurrent metastatic RCC.
已在各种恶性肿瘤的新生血管中观察到前列腺特异性膜抗原（PSMA）的表达。我们报告一例转移性肾细胞癌（RCC），对其进行了F-FDG PET/CT和Ga-PSMA-11成像对比，其中FDG PET/CT未能检测到转移性甲状腺疾病，且在其他部位显示出较少的F-FDG浓聚病灶，而Ga-PSMA-11 PET/CT则识别出转移性甲状腺疾病，并显示出强烈表达Ga-PSMA-11的远处转移病灶。Ga-PSMA-11 PET/CT可被视为一种在RCC中检测转移灶并指导特定治疗选择（如对复发性转移性RCC患者进行基于PSMA的放射性核素治疗）的潜在有用成像技术。
