Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Immunology, Berlin, Germany.
Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany.
Nat Commun. 2022 Aug 30;13(1):5104. doi: 10.1038/s41467-022-32507-6.
A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 syndrome patients (29 female/13 male, median age 36.5 years) with persistent moderate to severe fatigue and exertion intolerance six months following COVID-19. Further we evaluate an age- and sex-matched postinfectious non-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome cohort comparatively. Most post-COVID-19 syndrome patients are moderately to severely impaired in daily live. 19 post-COVID-19 syndrome patients fulfill the 2003 Canadian Consensus Criteria for myalgic encephalomyelitis/chronic fatigue syndrome. Disease severity and symptom burden is similar in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome and non-COVID-19/myalgic encephalomyelitis/chronic fatigue syndrome patients. Hand grip strength is diminished in most patients compared to normal values in healthy. Association of hand grip strength with hemoglobin, interleukin 8 and C-reactive protein in post-COVID-19 syndrome/non-myalgic encephalomyelitis/chronic fatigue syndrome and with hemoglobin, N-terminal prohormone of brain natriuretic peptide, bilirubin, and ferritin in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome may indicate low level inflammation and hypoperfusion as potential pathomechanisms.
一组患者在轻度至中度 2019 冠状病毒病（COVID-19）后会出现长期症状。在一项前瞻性观察队列研究中，我们分析了 42 例 COVID-19 后综合征患者（29 名女性/13 名男性，中位年龄 36.5 岁）的临床和实验室参数，这些患者在 COVID-19 后 6 个月持续出现中度至重度疲劳和体力活动不耐受。此外，我们比较性地评估了年龄和性别匹配的感染后非 COVID-19 肌痛性脑脊髓炎/慢性疲劳综合征队列。大多数 COVID-19 后综合征患者的日常生活中度至重度受损。19 例 COVID-19 后综合征患者符合 2003 年加拿大肌痛性脑脊髓炎/慢性疲劳综合征共识标准。COVID-19 后综合征/肌痛性脑脊髓炎/慢性疲劳综合征和非 COVID-19/肌痛性脑脊髓炎/慢性疲劳综合征患者的疾病严重程度和症状负担相似。与健康人相比，大多数患者的握力明显减弱。COVID-19 后综合征/非肌痛性脑脊髓炎/慢性疲劳综合征和 COVID-19 后综合征/肌痛性脑脊髓炎/慢性疲劳综合征患者的握力与血红蛋白、白细胞介素 8 和 C 反应蛋白相关，与血红蛋白、脑钠肽前体 N 端、胆红素和铁蛋白相关可能表明低水平炎症和灌注不足是潜在的发病机制。
