Landeskrankenhaus Hochzirl - Natters, In der Stille 20, Natters, 6161, Austria.
University of Salzburg, Mönchsberg 2a, Salzburg, 5020, Austria.
BMC Geriatr. 2022 Aug 31;22(1):717. doi: 10.1186/s12877-022-03368-x.
The activities of daily living (ADL) score is a widely used index to establish the degree of independence from any help in everyday life situations. Measuring ADL accurately is time-consuming and costly. This paper presents a framework to approximate ADL via variables usually collected in comprehensive geriatric assessments. We show that the selected variables serve as good indicators in explaining the physical disabilities of older patients.
Our sample included information from a geriatric assessment of 326 patients aged between 64 and 99 years in a hospital in Tyrol, Austria. In addition to ADL, 23 variables reflecting the physical and mental status of these patients were recorded during the assessment. We performed least absolute shrinkage and selection operator (LASSO) to determine which of these variables had the highest impact on explaining ADL. Then, we used receiver operating characteristic (ROC) analysis and logistic regression techniques to validate our model performance. Finally, we calculated cut-off points for each of the selected variables to show the values at which ADL fall below a certain threshold.
Mobility, urinary incontinence, nutritional status and cognitive function were most closely related to ADL and, therefore, to geriatric patients' functional limitations. Jointly, the selected variables were able to detect neediness with high accuracy (area under the ROC curve (AUC) = 0.89 and 0.91, respectively). If a patient had a limitation in one of these variables, the probability of everyday life disability increased with a statistically significant factor between 2.4 (nutritional status, 95%-CI 1.5-3.9) and 15.1 (urinary incontinence, 95%-CI 3.6-63.4).
Our study highlights the most important impairments of everyday life to facilitate more efficient use of clinical resources, which in turn allows for more targeted treatment of geriatric patients. At the patient level, our approach enables early detection of functional limitations and timely indications of a possible need for assistance in everyday life.
日常生活活动(ADL)评分是广泛用于确定日常生活中任何帮助程度的指标。准确测量 ADL 既耗时又昂贵。本文提出了一种通过通常在综合老年评估中收集的变量来近似 ADL 的框架。我们表明,所选变量可以很好地说明老年患者的身体残疾。
我们的样本包括来自奥地利蒂罗尔州一家医院的 326 名 64 至 99 岁患者的老年评估信息。除 ADL 外,在评估期间还记录了反映这些患者身体和精神状况的 23 个变量。我们使用最小绝对收缩和选择算子(LASSO)来确定这些变量中哪些对解释 ADL 有最大影响。然后,我们使用接收者操作特征(ROC)分析和逻辑回归技术来验证我们的模型性能。最后,我们为每个选定变量计算了截止值,以显示 ADL 低于特定阈值的值。
移动能力、尿失禁、营养状况和认知功能与 ADL 最密切相关,因此与老年患者的功能限制最密切相关。这些选定的变量共同能够以高精度检测需求(ROC 曲线下面积(AUC)分别为 0.89 和 0.91)。如果患者在这些变量中的一个方面存在限制,日常生活残疾的可能性会以统计学上显著的因素增加,从 2.4(营养状况,95%CI 1.5-3.9)到 15.1(尿失禁,95%CI 3.6-63.4)。
我们的研究强调了日常生活中最重要的障碍,以更有效地利用临床资源,从而更有针对性地治疗老年患者。在患者层面,我们的方法可以早期发现功能限制,并及时指出日常生活中可能需要帮助的迹象。