Maternal-Fetal Medicine Research Group, Department of Obstetrics, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hospital Universitario La Paz-Carlos III, Madrid, Spain.
BMC Pregnancy Childbirth. 2022 Aug 30;22(1):669. doi: 10.1186/s12884-022-04997-1.
To develop gestational age-based reference ranges for cervical length in triplet pregnancies. The secondary objective was to assess the performance of cervical length measured between 18 and 20 + 6 days for the prediction of preterm delivery before 28 and 32 weeks, respectively.
Observational retrospective study of triplet pregnancies in three Spanish tertiary-care hospitals between 2001 and 2019. Cervical length measurements were consecutively obtained between 15 and 34 weeks of gestation. Pregnancies undergoing multifetal reduction or fetal surgery were excluded.
Two hundred and six triplet pregnancies were included in the final analysis. There was a quadratic decrease in cervical length with gestational age. The median and fifth centiles for cervical length at 20 weeks were 35 and 13 mm. In the prediction of preterm birth < 28 weeks, for a false positive rate of 5%, and 10%, the detection rates were 40.9%, and 40.9%, respectively, and the prediction of preterm birth < 32 weeks, 22.0% and 26.0%, respectively.
In triplet pregnancies, cervical length decreases with gestational age. The performance of cervical length at 18-20 + 6 in screening for preterm birth before 28 and 32 weeks is poor.
制定基于孕龄的三胎妊娠宫颈长度参考范围。次要目的是评估 18-20+6 周测量的宫颈长度在预测分别为 28 周和 32 周前早产的表现。
这是一项在 2001 年至 2019 年间在西班牙三家三级保健医院进行的三胞胎妊娠的观察性回顾性研究。在妊娠 15-34 周连续测量宫颈长度。排除多胎减少或胎儿手术的妊娠。
最终分析包括 206 例三胞胎妊娠。宫颈长度随孕龄呈二次下降。20 周时宫颈长度的中位数和第五百分位数分别为 35 和 13mm。在预测早产<28 周时，假阳性率为 5%和 10%时，检出率分别为 40.9%和 40.9%，预测早产<32 周时，检出率分别为 22.0%和 26.0%。
在三胎妊娠中，宫颈长度随孕龄而下降。18-20+6 周的宫颈长度在筛查 28 周和 32 周前早产的表现不佳。
