新型冠状病毒2型血清阴性免疫：一项病例研究。
Seronegative immunity to SARS-CoV-2: a case study.
作者信息
Miller Kyle D, Ashcraft Amie M, Pilkerton Courtney S, Shrader Carl D
机构信息
Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA.
出版信息
Allergy Asthma Clin Immunol. 2022 Aug 30;18(1):80. doi: 10.1186/s13223-022-00715-w.
BACKGROUND
COVID-19 presents with a variable clinical course from asymptomatic to severe respiratory distress with nearly 25% mortality in mechanically-ventilated patients. As such, there is uncertainty regarding how host factors modulate the disease course.
CASE PRESENTATION
This report examines these factors in two geriatric patients with multiple comorbid conditions who were residents of the long-term care facility in West Virginia that was the epicenter of COVID-19 in the state. Each patient had substantial, unprotected exposure to SARS-CoV-2 with subsequent negative PCR and antibody testing.
CONCLUSIONS
These cases could represent an important step in understanding host factors that modulate the disease course and susceptibility of patients exposed to SARS-CoV-2, and illustrate the need for further research into host resistance relating to this pandemic.
背景
新型冠状病毒肺炎（COVID-19）的临床病程多样，从无症状到严重呼吸窘迫，机械通气患者的死亡率近25%。因此，关于宿主因素如何调节疾病进程存在不确定性。
病例报告
本报告研究了两名患有多种合并症的老年患者的这些因素，这两名患者是西弗吉尼亚州一家长期护理机构的居民，该机构是该州COVID-19的疫情中心。每名患者都大量、无防护地接触了严重急性呼吸综合征冠状病毒2（SARS-CoV-2），随后核酸检测和抗体检测均为阴性。
结论
这些病例可能是理解调节疾病进程的宿主因素以及接触SARS-CoV-2患者易感性的重要一步，并表明需要进一步研究与这一疫情相关的宿主抵抗力。
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