LINC01133在癌症中的作用综述。
A review on the role of LINC01133 in cancers.
作者信息
Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Mokhtari Majid
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Cancer Cell Int. 2022 Aug 30;22(1):270. doi: 10.1186/s12935-022-02690-z.
Long Intergenic Non-Protein Coding RNA 1133 (LINC01133) is a long non-coding RNA (lncRNA) which interacts with miR-106a-3p, miR-576-5p, miR-495-3p, miR-205, miR-199a-5p, miR-4784, miR-30a-5p, miR-199a, miR-30b-5p, miR-216a -5p and miR-422a, thus increasing expression of mRNA targets of these miRNAs. LINC01133 can affect cancer metastasis through regulation of epithelial-mesenchymal transition program. Dysregulation of this lncRNA has been repeatedly detected in the process of tumorigenesis. In this review, we summarize the results of various studies that reported dysregulation of LINC01133 in different samples and described the role of this lncRNA as a marker for these disorders.
长链基因间非编码RNA 1133（LINC01133）是一种长链非编码RNA（lncRNA），它与miR-106a-3p、miR-576-5p、miR-495-3p、miR-205、miR-199a-5p、miR-4784、miR-30a-5p、miR-199a、miR-30b-5p、miR-216a-5p和miR-422a相互作用，从而增加这些miRNA的mRNA靶标的表达。LINC01133可通过调节上皮-间质转化程序影响癌症转移。在肿瘤发生过程中，反复检测到这种lncRNA的失调。在本综述中，我们总结了各种研究的结果，这些研究报告了LINC01133在不同样本中的失调情况，并描述了这种lncRNA作为这些疾病标志物的作用。
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