Kirchgessner M, Plank J, Roth H P
Z Ernahrungswiss. 1987 Mar;26(1):1-6. doi: 10.1007/BF02023815.
In order to study the effect of alimentary zinc deficiency on vitamin A and alpha-tocopherol metabolism, weaned, male Sprague-Dawley rats with a mean weight of 48 g were divided into three groups. Zinc depletion animals (n = 7) were provided a half-synthetic, casein-based diet with a zinc concentration of 1.3 ppm; the pair-fed (n = 7) and ad libitum-fed (n = 6) control animals were given a diet containing 96 ppm zinc. After 24 days, the serum zinc level for depletion animals was 80% lower than the level for the two control groups, although the vitamin A, beta-carotine and tocopherol concentrations in deficiency animals and in pair-fed control animals did not differ significantly from one another. In comparison with adlibitum-fed control rats, however, vitamin A and beta-carotine concentrations in depletion and pair-fed animals were elevated. The zinc concentration in livers of deficiency animals was reduced only in comparison to the value for pair-fed control animals, while the vitamin A, beta-carotine and alpha-tocopherol concentrations in livers of zinc-deficient animals were reduced in comparison to the values for both of the control groups. Nevertheless, these changes are less likely a result of zinc deficiency per se, but rather are more likely a result of the lowered feed intake during zinc deficiency and the reduced growth.
为了研究膳食锌缺乏对维生素A和α-生育酚代谢的影响，将平均体重为48克的断奶雄性斯普拉格-道利大鼠分为三组。锌缺乏组动物（n = 7）给予锌浓度为1.3 ppm的半合成酪蛋白基饲料；配对喂养组（n = 7）和自由采食组（n = 6）对照动物给予含96 ppm锌的饲料。24天后，缺乏组动物的血清锌水平比两个对照组低80%，尽管缺乏组动物和配对喂养对照组动物的维生素A、β-胡萝卜素和生育酚浓度彼此之间没有显著差异。然而，与自由采食对照大鼠相比，缺乏组和配对喂养组动物的维生素A和β-胡萝卜素浓度升高。缺乏组动物肝脏中的锌浓度仅与配对喂养对照动物的值相比有所降低，而锌缺乏组动物肝脏中的维生素A、β-胡萝卜素和α-生育酚浓度与两个对照组的值相比均降低。然而，这些变化不太可能是锌缺乏本身的结果，而更可能是锌缺乏期间采食量降低和生长减缓的结果。
