Khanna Shefali, Puckett Yana
Department of Surgery, Charleston Area Medical Center, Charleston, USA.
Cureus. 2022 Jul 27;14(7):e27358. doi: 10.7759/cureus.27358. eCollection 2022 Jul.
While shortcomings in the detection of invasive lobular carcinoma (ILC) continue to be studied, research is ongoing to determine detection rates using current breast imaging modalities in combination with physical examination findings. In the following case report, we describe the rare presentation of a patient diagnosed by punch biopsy with grade III, estrogen receptor (ER)-/progesterone receptor (PR)-positive invasive lobular carcinoma with intradermal invasion. This patient presented with findings similar to inflammatory breast cancer (IBC) including pain in the left nipple, skin warmth, and erythema circumferentially encompassing approximately two-thirds of the left breast. This case study is of significance as, to date, it is the first report of an invasive lobular carcinoma that presented clinically as inflammatory breast cancer and was occult on both diagnostic mammography and ultrasound. While imaging remains the primary method of breast cancer detection, it is important to note that clinical findings of dermal invasion of the breast may prompt further investigation with a biopsy and close follow-up, regardless of imaging results.
虽然浸润性小叶癌（ILC）检测方面的不足仍在研究中，但目前正在进行研究以确定使用当前乳腺成像模式结合体格检查结果的检测率。在以下病例报告中，我们描述了一名通过穿刺活检诊断为III级、雌激素受体（ER）/孕激素受体（PR）阳性且伴有真皮侵犯的浸润性小叶癌患者的罕见表现。该患者的表现类似于炎性乳腺癌（IBC），包括左侧乳头疼痛、皮肤发热以及环绕左侧乳房约三分之二的红斑。本病例研究具有重要意义，因为迄今为止，这是首例临床上表现为炎性乳腺癌且在诊断性乳腺X线摄影和超声检查中均隐匿的浸润性小叶癌报告。虽然成像仍然是乳腺癌检测的主要方法，但需要注意的是，无论成像结果如何，乳腺真皮侵犯的临床发现可能会促使进行活检并密切随访。
