Department of General Surgery, Gülhane Training and Research Hospital, Ankara-Türkiye.
Department of General Surgery, Selçuk University Faculty of Medicine, Konya-Türkiye.
Ulus Travma Acil Cerrahi Derg. 2022 Sep;28(9):1205-1213. doi: 10.14744/tjtes.2021.31526.
Capparis ovata contains alkaloids, lipids, polyphenols, flavonoids, and also is rich in antioxidants. Conventionally, in Turkey, the flower buds, root, bark, and fruits of C. ovata are used for their analgesic, anti-inflammatory, anti-rheumatism, tonic, and diuretic effects. The aim of this study was to examine the effect on wound healing of C. ovata seed oil (COSO), which is known to have antioxidant, anti-inflammatory, and antibacterial properties.
In the study, 20 Wistar albino female rats were randomly divided into two groups of 10 animals each. A standard full-thickness skin defect was created on the back area of the rats. In both groups, after cleaning the wounds with saline daily, no active substance other than saline was applied to the control group, while 1 cc/day COSO was applied to the wounds of the rats in the study group. On the post-operative 14th day, the rats were reanesthetized and wound area measurements were made. Then, excision was performed to include 1 cm of intact tissue around the wound, which remained unhealed, and samples were taken for histopathological examination.
The changes in wound areas showed that after 14 days, the improvement in the group treated with caper oil (32.78; 95% confidence interval, 17.21-48.36) was significantly higher than that of the control group (65.41; 95% confidence interval, 49.84-80.98) (p=0.009). The histopathological scores showed a significant difference between the groups in respect of epithelial formation, inflam-mation, and fibrosis development. No epithelial tissue formation was observed in the control group (90%), and more incomplete re-epithelization and focal epidermal hyperplasia were observed in the treatment group (60%). Fibrosis development was mild and weak (70%) in the control group and was evaluated as severe and intense (60%) in the treatment group. Perivascular edema was mild (50%) and vascularity was immature (60% - an indicator of neovascularization) in the treatment group. These histopathological results showed that the treatment group inflammation phase was completed and the proliferation phase started, as well as the effectiveness of the use of caper oil on epithelization, angiogenesis, and fibrosis, which are important histopathological parameters in the evaluation of wound healing compared to the control group.
From the results of this study, it was concluded that COSO significantly enhances the healing of full-thickness skin wounds and this effect is primarily related to its anti-inflammatory effect.
山柑含有生物碱、脂类、多酚、类黄酮，并且富含抗氧化剂。传统上，在土耳其，山柑的花蕾、根、树皮和果实被用于其止痛、抗炎、抗风湿、滋补和利尿作用。本研究的目的是研究山柑籽油（Coso）对伤口愈合的影响，Coso 具有抗氧化、抗炎和抗菌特性。
在这项研究中，20 只 Wistar 白化雌性大鼠被随机分为两组，每组 10 只动物。在大鼠背部区域创建标准的全层皮肤缺损。在两组中，每天用生理盐水清洗伤口后，对照组除生理盐水外不使用任何活性物质，而研究组的大鼠伤口每天应用 1 毫升 Coso。在术后第 14 天，对大鼠进行重新麻醉并测量伤口面积。然后，进行切除以包括未愈合的伤口周围 1 厘米的完整组织，并采集样本进行组织病理学检查。
伤口面积的变化表明，在接受山柑油治疗的组（32.78；95%置信区间，17.21-48.36）中，在第 14 天的改善明显高于对照组（65.41；95%置信区间，49.84-80.98）（p=0.009）。组织病理学评分显示，两组在上皮形成、炎症和纤维化发展方面存在显著差异。对照组（90%）未见上皮组织形成，治疗组（60%）可见不完全再上皮化和局灶性表皮增生。对照组（70%）纤维化发展轻微且较弱，治疗组（60%）评估为严重且强烈。对照组（50%）可见血管周围水肿轻微，血管不成熟（60%——新生血管的指标），治疗组。这些组织病理学结果表明，治疗组炎症期已完成，增殖期已开始，山柑油对上皮化、血管生成和纤维化的作用有效，与对照组相比，这是评价伤口愈合的重要组织病理学参数。
从这项研究的结果可以得出结论，Coso 显著促进全层皮肤伤口愈合，这种作用主要与其抗炎作用有关。
