Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Tepebasi TR-26470, Eskisehir, Turkey.
J Ethnopharmacol. 2010 Aug 19;131(1):28-32. doi: 10.1016/j.jep.2010.05.060. Epub 2010 Jun 4.
Capparis ovata Desf. and Capparis spinosa L. have wide natural distribution in Turkey and they are consumed in pickled form. Flower buds, root bark, and fruits of the plant are used in folk medicine due to their analgesic, wound healing, cell regeneration, tonic, and diuretic effects.
In this study, we attempted to identify the possible antinociceptive action of methanol extract prepared from fruits of Capparis ovata.
Using tail immersion, hot plate and writhing tests, the antinociceptive effect of the methanol extract of Capparis ovata (MEC) fruits was assessed after intraperitoneal administration into mice. Morphine sulfate (5mg/kg; i.p.) and diclofenac (10mg/kg; i.p.) were used as reference analgesic agents. Naloxone (5mg/kg; i.p.) was also tested.
MEC was studied at the doses of 50, 100, and 200mg/kg (i.p.) and exhibited significant antinociceptive activities in all tests used. The above-mentioned doses of the extract reduced the writhing responses by 32.21, 55.70, and 68.36%, respectively. MPE% were increased by 7.27, 12.07, 14.60% in the tail immersion, and 7.88, 11.71, 16.73% in the hot plate test at the tested doses, respectively. Naloxone antagonized antinociceptive effect at the doses of 100 and 200mg/kg whereas partially antagonized the effect of MEC at the dose of 50mg/kg.
Based on the results obtained, it can be concluded that MEC has antinociceptive effects both at the peripheral and central levels.
卡帕里斯奥瓦塔迪斯夫和卡帕里斯斯宾塞洛在土耳其有广泛的自然分布，它们以腌制的形式被食用。由于其具有镇痛、愈合伤口、细胞再生、滋补和利尿作用，植物的花蕾、根皮和果实被用于民间医学。
在这项研究中，我们试图确定从卡帕里斯奥瓦塔果实中制备的甲醇提取物的可能的镇痛作用。
通过尾浸、热板和扭体试验，评估了卡帕里斯奥瓦塔甲醇提取物（MEC）果实经腹腔给药后对小鼠的镇痛作用。硫酸吗啡（5mg/kg；ip）和双氯芬酸（10mg/kg；ip）用作参考镇痛剂。还测试了纳洛酮（5mg/kg；ip）。
MEC 在 50、100 和 200mg/kg（ip）的剂量下进行了研究，在所有使用的试验中均表现出显著的镇痛活性。上述剂量的提取物分别使扭体反应减少了 32.21%、55.70%和 68.36%。在尾浸试验中，MPE%分别增加了 7.27%、12.07%和 14.60%，在热板试验中分别增加了 7.88%、11.71%和 16.73%。纳洛酮在 100 和 200mg/kg 的剂量下拮抗了镇痛作用，而在 50mg/kg 的剂量下部分拮抗了 MEC 的作用。
根据所得结果，可以得出结论，MEC 具有外周和中枢水平的镇痛作用。
