Brain Glioma Center, Department of Neurosurgery, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, China.
Mol Biol Rep. 2022 Nov;49(11):10949-10959. doi: 10.1007/s11033-022-07809-z. Epub 2022 Aug 31.
Malignant tumor cells can obtain proliferative benefits from deviant metabolic networks. Emerging evidence suggests that lipid metabolism are dramatically altered in gliomas and excessive fatty acd accumulation is detrimentally correlated with the prognosis of glioma patients. Glioma cells possess remarkably high levels of free fatty acids, which, in turn, enhance post-translational modifications (e.g. palmitoylation). Our and other groups found that palmitoylational modification is essential for remaining intracellular homeostasis and cell survival. Disrupting the balance between palmitoylation and depalmitoylation affects glioma cell viability, apoptosis, invasion, self-renew and pyroptosis. In this review, we focused on summarizing roles and relevant mechanisms of protein palmitoylational modification in gliomas.
恶性肿瘤细胞可以从异常的代谢网络中获得增殖优势。新出现的证据表明，脂代谢在神经胶质瘤中发生了显著改变，并且脂肪酸的过度积累与神经胶质瘤患者的预后呈负相关。神经胶质瘤细胞具有极高水平的游离脂肪酸，而游离脂肪酸反过来又增强了翻译后修饰（如棕榈酰化）。我们和其他研究小组发现，棕榈酰化修饰对于维持细胞内的稳态和细胞存活是必不可少的。破坏棕榈酰化和去棕榈酰化之间的平衡会影响神经胶质瘤细胞的活力、凋亡、侵袭、自我更新和细胞焦亡。在这篇综述中，我们重点总结了蛋白质棕榈酰化修饰在神经胶质瘤中的作用和相关机制。
