Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, 1400 S. Coulter St., Amarillo, TX, 79106, USA.
Texas Tech University Health Sciences Center School of Medicine, Amarillo, TX, USA.
Arch Sex Behav. 2022 Oct;51(7):3647-3651. doi: 10.1007/s10508-022-02409-1. Epub 2022 Aug 31.
The biopsychosocial etiology of gender dysphoria is poorly understood, but current thought suggests a complex interaction of genetic, hormonal, environmental, and differences in brain development and physiology. Twin studies have implicated a genetic role in the formation of gender identity. Congruence for gender dysphoria is more common among monozygotic twins compared to dizygotic twins. We present a case of monozygotic (identical) triplets who have each transitioned from female to male under the care of a university transgender health service. Each triplet experienced gender dysphoria from childhood and has undergone transitional endocrine care and various aspects of gender-affirming surgery. Although a pure genetic or biological component cannot be attributed as a cause of their gender dysphoria with absolute certainty since the triplets were raised together, this unusual case of gender dysphoria among a set of monozygotic triplets adds support for a heritable role in gender identity formation.
性别焦虑症的生物心理社会病因尚不清楚，但目前的观点认为，遗传、激素、环境以及大脑发育和生理差异之间存在复杂的相互作用。双胞胎研究表明，遗传在性别认同的形成中起作用。同卵双胞胎的性别焦虑症一致性高于异卵双胞胎。我们报告了一例单卵（同卵）三胞胎的病例，他们在一所大学跨性别健康服务机构的照料下，分别从女性转变为男性。每个三胞胎从童年开始就经历了性别焦虑症，并接受了过渡性内分泌治疗和各种性别肯定手术。尽管由于三胞胎一起长大，不能绝对肯定地将纯粹的遗传或生物学因素归因于他们的性别焦虑症的原因，但这一组同卵三胞胎中出现的不寻常性别焦虑症病例为性别认同形成中的遗传作用提供了支持。
