Int J Gynecol Pathol. 2023 May 1;42(3):278-281. doi: 10.1097/PGP.0000000000000919. Epub 2022 Aug 31.
Primary cutaneous neuroendocrine tumors (CNET) are extremely rare. Only a few cases have been reported so far. CNET have an indolent clinical course and usually present as a single flesh-colored nodule with a predilection for the scalp and trunk in elderly patients. While primary CNET have characteristic histological and immunohistochemical features akin to other low-grade neuroendocrine tumors elsewhere in the body, diagnosing these tumors on skin biopsies can be challenging as they are particularly mistaken for other, more commonly diagnosed, entities. In the current report we present a unique case of primary CNET of the vulva. The clinical presentation will be discussed as well as the histopathologic and immunohistochemical features and most importantly the possible pitfalls in microscopic examination.
原发性皮肤神经内分泌肿瘤（CNET）极为罕见。迄今为止，仅报道了少数病例。CNET 具有惰性的临床病程，通常表现为单个肤色结节，好发于老年患者的头皮和躯干。虽然原发性 CNET 具有与身体其他部位其他低级别神经内分泌肿瘤相似的特征性组织学和免疫组织化学特征，但在皮肤活检中诊断这些肿瘤具有挑战性，因为它们特别容易被误诊为其他更常见的诊断实体。在本报告中，我们介绍了一例外阴原发性 CNET 的独特病例。将讨论其临床表现、组织病理学和免疫组织化学特征，以及最重要的是显微镜检查中的可能陷阱。
