Fónyad G, Rosta A, Tóth E K, Szaleczky E, Katona C, Sápi Z, Ungár L, Poller I
Semmelweis Orvostudományi Egyetem Oktató Kórház, I. Belgyógyászati és Kemoterápiás Osztály, Budapest.
Orv Hetil. 1997 Jun 29;138(26):1695-7.
Merkel cell cancer is a rare carcinoma arising from the neuroendocrin cells of the skin. The diagnosis is based on the clinical behaviour, histopathologic and ultrastructural findings and immunohistochemical results. An unusual case of Merkel cell carcinoma is presented. Mass from the umbiculus and a right inguinal lymph node was excised in a 63-year-old female. The histologic features of a typical, primitive small cell tumor combined with the immunohistochemical evaluations established the diagnosis. Rare polynuclear giant cells were focally present in our case. Patient was treated with combination of chemotherapy (Cisplatin, Etoposid) and radiotherapy. Control examinations showed complete respond. One year later metastasis developed. Resection of all known metastasis were performed. Two months after the laparotomy she died of metastatic disease. The autopsy did not reveal any other primary tumor. The capricious nature of the clinical course and the differences between this tumor and other carcinomas is emphasized.
默克尔细胞癌是一种起源于皮肤神经内分泌细胞的罕见癌。诊断基于临床行为、组织病理学和超微结构发现以及免疫组化结果。本文报道了一例不寻常的默克尔细胞癌病例。一名63岁女性切除了来自脐部和右侧腹股沟淋巴结的肿块。典型的原始小细胞肿瘤的组织学特征结合免疫组化评估确立了诊断。在我们的病例中局部可见罕见的多核巨细胞。患者接受了化疗（顺铂、依托泊苷）和放疗联合治疗。对照检查显示完全缓解。一年后发生转移。对所有已知转移灶进行了切除。剖腹手术后两个月，她死于转移性疾病。尸检未发现任何其他原发性肿瘤。强调了该肿瘤临床病程的多变性以及它与其他癌之间的差异。
