Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium.
Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, 71345-1978, Iran.
J Mater Chem B. 2022 Aug 10;10(31):5873-5912. doi: 10.1039/d2tb01056a.
Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid interacts with various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins and polysaccharides hydrogen bonding, electrostatic, coordinative bonding, and hydrophobic interactions. Tannic acid has been studied for various biomedical applications as a natural crosslinker with anti-inflammatory, antibacterial, and anticancer activities. In this review, we focus on TA-based hydrogels for biomaterials engineering to help biomaterials scientists and engineers better realize TA's potential in the design and fabrication of novel hydrogel biomaterials. The interactions of TA with various natural or synthetic compounds are deliberated, discussing parameters that affect TA-material interactions thus providing a fundamental set of criteria for utilizing TA in hydrogels for tissue healing and regeneration. The review also discusses the merits and demerits of using TA in developing hydrogels either through direct incorporation in the hydrogel formulation or indirectly immersing the final product in a TA solution. In general, TA is a natural bioactive molecule with diverse potential for engineering biomedical hydrogels.
单宁酸（TA）是一种天然多酚，是没食子酸的可水解两亲性单宁衍生物，其结构中含有多个没食子酰基。单宁酸与各种有机、无机、亲水和疏水材料相互作用，如蛋白质和多糖，通过氢键、静电、配位键和疏水相互作用。单宁酸因其具有抗炎、抗菌和抗癌活性，作为一种天然交联剂，已被用于多种生物医学应用的研究。在这篇综述中，我们专注于基于 TA 的水凝胶在生物材料工程中的应用，以帮助生物材料科学家和工程师更好地实现 TA 在设计和制造新型水凝胶生物材料方面的潜力。本文讨论了 TA 与各种天然或合成化合物的相互作用，探讨了影响 TA-材料相互作用的参数，从而为在组织修复和再生的水凝胶中利用 TA 提供了一套基本的标准。本综述还讨论了在开发水凝胶时直接纳入水凝胶配方或间接将最终产品浸泡在 TA 溶液中使用 TA 的优缺点。总的来说，TA 是一种具有多种潜力的天然生物活性分子，可用于工程生物医学水凝胶。
