Suitthimeathegorn Orawan, Yang Cheng, Ma Yanyun, Liu Wei
Medical Affairs, Johnson & Johnson, Singapore, Singapore.
Cosmetics Innovation Center, School of Chemical and Material Engineering, Jiangnan University, Wuxi, China.
Skin Pharmacol Physiol. 2022;35(6):305-318. doi: 10.1159/000526720. Epub 2022 Aug 31.
The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400-500 nm). Although some progress has been made in the study of the biological effects of blue light on the skin, many questions in this field remain unexplored. The aim of this article was to review the currently available evidence on the deleterious effects of blue light on the skin as well as the methods and strategies designed to protect from the detrimental effects of blue light. The PubMed and ProQuest databases were searched in January 2022. Search results were supplemented by articles considered relevant by the authors.
The results of in vitro, in vivo, and clinical studies show that blue light produces direct and indirect effects on the skin. The most significant direct effects are the excessive generation of reactive oxygen and nitrogen species, and hyperpigmentation. Reactive oxygen and nitrogen species cause DNA damage and modulate the immune response. Indirect effects of blue light include disruption of the central circadian rhythm regulation via melatonin signaling and local circadian rhythm regulation via direct effects on skin cells. Antioxidants and sunscreens containing titanium dioxide, iron oxides, and zinc oxide can be used to protect against the detrimental effects of blue light as part of a strategy that combines daytime protection and night-time repair.
Blue light produces a wide variety of direct and indirect effects on the skin. As exposure to blue light from artificial sources is likely to continue to increase, this area warrants further investigation.
近几十年来，电子设备和其他人工光源的使用日益增加，改变了蓝光（400 - 500纳米）的暴露模式。尽管在蓝光对皮肤的生物学效应研究方面已经取得了一些进展，但该领域仍有许多问题有待探索。本文的目的是综述目前关于蓝光对皮肤有害影响的现有证据，以及旨在防止蓝光有害影响的方法和策略。于2022年1月检索了PubMed和ProQuest数据库。作者认为相关的文章对检索结果进行了补充。
体外、体内和临床研究结果表明，蓝光对皮肤产生直接和间接影响。最显著的直接影响是活性氧和氮物种的过度产生以及色素沉着过度。活性氧和氮物种会导致DNA损伤并调节免疫反应。蓝光的间接影响包括通过褪黑素信号破坏中枢昼夜节律调节以及通过对皮肤细胞的直接作用破坏局部昼夜节律调节。含有二氧化钛、氧化铁和氧化锌的抗氧化剂和防晒霜可作为白天防护和夜间修复相结合策略的一部分，用于防止蓝光的有害影响。
蓝光对皮肤产生多种直接和间接影响。由于来自人工光源的蓝光暴露可能会持续增加，这一领域值得进一步研究。
