Zhang Ditte Georgina, Zahid Jawad Ahmad, Ali Zarqa, Thomsen Simon Francis
Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dermatology. 2023;239(1):32-44. doi: 10.1159/000525870. Epub 2022 Aug 31.
Chronic urticaria (CU) has been associated with several systemic and autoimmune disorders. The association with atopic disorders is however controversial. The objective of this study was to perform a systematic review and meta-analysis to assess the association between CU and the atopic disorders: atopic dermatitis (AD), asthma, and allergic rhinoconjunctivitis (ARC).
Search hits from PubMed, Embase, Cochrane Library, and Web of Science were systematically reviewed. English papers from 2000 to present, containing original data of the association (prevalence, incidence, or risk) between CU and any atopic disorder(s), were included. Pooled point prevalence and OR with 95% confidence intervals were calculated with a random effects model.
A total of 8,108 search hits were screened and reviewed. Thirty-eight studies met all inclusion criteria. The estimated pooled point prevalence of AD, asthma, and ARC in CU was 7% (5-11%, I2 = 99%), 12% (9-15%, I2 = 100%), and 22% (16-29%, I2 = 100%), respectively. Pooled ORs were estimated to 2.75 (2.05-3.68, I2 = 94%) for AD, 1.87 (1.01-3.45, I2 = 100%) for asthma, and 2.94 (1.84-4.68, I2 = 100%) for ARC.
Pooled point prevalences of atopic disorders in CU were comparable to the general population. However, studies that compared prevalences with controls from the same population all found a significantly increased risk of atopic disorders in CU. Results should however be interpreted with caution as high heterogeneity was found in all analyses.
慢性荨麻疹（CU）与多种全身性和自身免疫性疾病有关。然而，其与特应性疾病的关联存在争议。本研究的目的是进行系统评价和荟萃分析，以评估CU与特应性疾病（特应性皮炎（AD）、哮喘和变应性鼻结膜炎（ARC））之间的关联。
对来自PubMed、Embase、Cochrane图书馆和科学网的检索结果进行系统评价。纳入2000年至今包含CU与任何特应性疾病之间关联（患病率、发病率或风险）原始数据的英文论文。采用随机效应模型计算合并点患病率和95%置信区间的OR值。
共筛选和评价了8108条检索结果。38项研究符合所有纳入标准。CU中AD、哮喘和ARC的估计合并点患病率分别为7%（5 - 11%，I² = 99%）、12%（9 - 15%，I² = 100%）和22%（16 - 29%，I² = 100%）。AD的合并OR值估计为2.75（2.05 - 3.68，I² = 94%），哮喘为1.87（1.01 - 3.45，I² = 100%），ARC为2.94（1.84 - 4.68，I² = 100%）。
CU中特应性疾病的合并点患病率与一般人群相当。然而，将患病率与同一人群的对照组进行比较的研究均发现CU中特应性疾病的风险显著增加。然而，由于所有分析中均发现高度异质性，结果应谨慎解释。
