Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Cell Rep. 2022 Aug 30;40(9):111298. doi: 10.1016/j.celrep.2022.111298.
Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs detected in the blood of cancer patients is associated with a worse prognosis. CTCs face critical challenges for their survival in circulation, such as anoikis, shearing forces, and immune surveillance. Thus, understanding the mechanisms and interactions of CTCs within the blood microenvironment is crucial for better understanding of metastatic progression and the development of novel treatment strategies. CTCs interact with different hematopoietic cells, such as platelets, red blood cells, neutrophils, macrophages, natural killer (NK) cells, lymphocytes, endothelial cells, and cancer-associated fibroblasts, which can affect CTC survival in blood. This interaction may take place either via direct cell-cell contact or through secreted molecules. Here, we review interactions of CTCs with blood cells and discuss the potential clinical relevance of these interactions as biomarkers or as targets for anti-metastatic therapies.
循环肿瘤细胞 (CTC) 是远处转移的种子，癌症患者血液中检测到的 CTC 数量与预后不良相关。CTC 在循环中存活面临着严峻的挑战，如失巢凋亡、剪切力和免疫监视。因此，了解 CTC 在血液微环境中的机制和相互作用对于更好地理解转移进展和开发新的治疗策略至关重要。CTC 与不同的造血细胞相互作用，如血小板、红细胞、中性粒细胞、巨噬细胞、自然杀伤 (NK) 细胞、淋巴细胞、内皮细胞和癌相关成纤维细胞，这些相互作用会影响 CTC 在血液中的存活。这种相互作用可以通过直接的细胞-细胞接触或通过分泌分子发生。在这里，我们综述了 CTC 与血细胞的相互作用，并讨论了这些相互作用作为生物标志物或作为抗转移治疗靶点的潜在临床相关性。
