Université Côte d'Azur, CHU Nice, FHU OncoAge, 06000 Nice, France.
Université Côte d'Azur, CNRS UMR7284, Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), FHU OncoAge, 06000 Nice, France.
Cells. 2019 Jul 13;8(7):714. doi: 10.3390/cells8070714.
Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in distant parenchyma. Most of the CTCs released in the blood stream will not resist those challenges and will consequently fail to induce metastasis. A few of them, however, interact closely with other blood cells, such as neutrophils, platelets, and/or macrophages to survive in the blood stream. Recent studies demonstrated that the interaction and modulation of the blood microenvironment by CTCs is pivotal for the development of new metastasis, making it an interesting target for potential novel treatment strategies. This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies.
通常，循环肿瘤细胞（CTC）被描述为癌症患者转移的来源。然而，在这个过程中，原发性肿瘤部位的癌细胞需要在离开循环系统成为远处实质中新转移部位的种子之前，在血流中经受住物理和生物学的挑战。在血流中释放的大多数 CTC 都无法抵抗这些挑战，因此无法引发转移。然而，其中一些 CTC 与其他血细胞（如中性粒细胞、血小板和/或巨噬细胞）密切相互作用，以在血流中存活。最近的研究表明，CTC 与血液微环境的相互作用和调节对新转移的发展至关重要，使其成为潜在新型治疗策略的一个有趣目标。这篇综述将讨论最近关于 CTC 与血液微环境相互作用的研究，并概述目前正在研究的治疗策略。
