Bhatia Tanuja, Gupta Ghanshyam Das, Kurmi Balak Das, Singh Dilpreet
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India.
Pharm Nanotechnol. 2022;10(5):342-353. doi: 10.2174/2211738510666220831113857.
Pulmonary arterial hypertension (PAH) is an uncommon condition marked by elevated pulmonary artery pressure that leads to right ventricular failure. The majority of drugs are now being approved by FDA for PAH, however, several biopharmaceutical hindrances lead to failure of the therapy. Various novel drug delivery systems are available in the literature from which lipid-based nanoparticles i.e. solid lipid nanoparticle is widely investigated for improving the solubility and bioavailability of drugs. In this paper, the prototype phytoconstituents used in pulmonary arterial hypertension have limited solubility and bioavailability. We highlighted the novel concepts of SLN for lipophilic phytoconstituents with their potential applications. This paper also reviews the present state of the art regarding production techniques for SLN like High-Pressure Homogenization, Microemulsion Technique, and Phase Inversion Temperature Method, etc. Furthermore, toxicity aspects and in vivo fate of SLN are also highlighted in this review. In a nutshell, safer delivery of phytoconstituents by SLN added a novel feather to the cap of successful drug delivery technologies.
肺动脉高压（PAH）是一种罕见的病症，其特征为肺动脉压力升高，进而导致右心室衰竭。目前大多数药物已获美国食品药品监督管理局（FDA）批准用于治疗PAH，然而，一些生物制药方面的障碍导致治疗失败。文献中介绍了各种新型药物递送系统，其中基于脂质的纳米颗粒，即固体脂质纳米粒，因其能提高药物的溶解度和生物利用度而受到广泛研究。在本文中，用于肺动脉高压治疗的原型植物成分的溶解度和生物利用度有限。我们着重介绍了固体脂质纳米粒用于亲脂性植物成分的新概念及其潜在应用。本文还综述了固体脂质纳米粒生产技术的现状，如高压均质法、微乳技术和相转变温度法等。此外，本综述还强调了固体脂质纳米粒的毒性方面及其体内命运。简而言之，通过固体脂质纳米粒更安全地递送植物成分，为成功的药物递送技术增添了新的亮点。
