Amirian Zahra, Zardast Mahmoud, Najmodini Mohsen, Moghadam Mohammadreza Ghasemian
Surgical Resident, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Medical Toxicology & Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Ann Med Surg (Lond). 2022 Jul 11;80:104129. doi: 10.1016/j.amsu.2022.104129. eCollection 2022 Aug.
Intra-abdominal adhesions (IAAs) are secondary to peritoneal injuries such as previous surgery or intra-abdominal infections (IAIs). Accordingly, it is crucial to employ fitting techniques to minimize the likelihood of adhesions in any surgery. Due to a paucity of similar data available, this study sought to explore the effects of induced high serum ascites albumin gradient (SAAG) and low serum ascites albumin gradient (SAAG) on the rate of post-operative microscopic and macroscopic adhesion in a mouse model.
Sixty mice were compared in six groups of ten each. Control groups (1 &4) received normal saline, groups 2&5 received high SAAG ascites fluid, and groups 3&6 received low SAAG ascites fluid intraperitoneally. These groups underwent exploratory laparotomy on day zero, followed by the same procedure on the 10th (groups 1,2,3) and the 30th (Groups 4,5,6) day of surgery. Then, microscopic and macroscopic IAAs were evaluated. Data were analyzed in SPSS software and compared with a p-value less than 0.05.
By comparison, the least microscopic and macroscopic IAAs after 10 and 30 days were found in the low SAAG ascites group. Revealing a statistically significant difference compared to the other two groups (P = 0.01). After 10 days of surgery, macroscopic IAA in the high SAAG group was significantly lower compared to the control and Low SAAG ascites groups.
Intraabdominal low SAAG ascites fluid can significantly decrease the probability of postoperative fibrosis and adhesion band formation.
IR. BUMS.REC.1399.503.
腹腔内粘连（IAA）继发于腹膜损伤，如既往手术或腹腔内感染（IAI）。因此，在任何手术中采用合适的技术以尽量减少粘连的可能性至关重要。由于缺乏类似数据，本研究旨在探讨诱导高血清腹水白蛋白梯度（SAAG）和低血清腹水白蛋白梯度（SAAG）对小鼠模型术后微观和宏观粘连发生率的影响。
60只小鼠分为6组，每组10只。对照组（1组和4组）腹腔内注射生理盐水，2组和5组腹腔内注射高SAAG腹水，3组和6组腹腔内注射低SAAG腹水。这些组在第0天进行剖腹探查术，然后在术后第10天（1组、2组、3组）和第30天（4组、5组、6组）进行相同的手术。然后，评估微观和宏观IAA。数据在SPSS软件中进行分析，并与p值小于0.05进行比较。
相比之下，低SAAG腹水组在术后10天和30天后的微观和宏观IAA最少。与其他两组相比有统计学显著差异（P = 0.01）。术后10天，高SAAG组的宏观IAA明显低于对照组和低SAAG腹水组。
腹腔内低SAAG腹水可显著降低术后纤维化和粘连带形成的概率。
IR. BUMS.REC.1399.503。
