Okabayashi Koji, Ashrafian Hutan, Zacharakis Emmanouil, Hasegawa Hirotoshi, Kitagawa Yuko, Athanasiou Thanos, Darzi Ara
The Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM-Building, Praed Street, London, W2 1NY, UK.
Surg Today. 2014 Mar;44(3):405-20. doi: 10.1007/s00595-013-0591-8. Epub 2013 May 9.
Abdominal adhesions are associated with increased postoperative complications, cost and workload. We performed a systematic review with statistical pooling to estimate the formation rate, distribution and severity of postoperative adhesions in patients undergoing abdominal surgery. A literature search was carried out for all articles reporting on the incidence, distribution and severity of adhesions between January 1990 and July 2011. Twenty-five articles fulfilled the inclusion criteria. The weighted mean formation rate of adhesions after abdominal surgery was 54 % (95 % confidence interval [CI] 40-68 %), and was 66 % (95 % CI 38-94 %) after gastrointestinal surgery, 51 % (95 % CI 40-63 %) after obstetric and gynaecological surgery and 22 % (95 % CI 7-38 %) after urological surgery. The mean overall severity score was 1.11 ± 0.98 according to the Operative Laparoscopy Study Group classification. Laparoscopic surgery reduced the adhesion formation rate by 25 % and decreased the adhesion severity score (laparoscopic; 0.36 ± 0.69 vs. open; 2.14 ± 0.84) for gastrointestinal surgery. Our results demonstrate that the incidence and severity of abdominal adhesions varies between surgical specialties and procedures. An increased awareness of adhesions can help in identifying the underlying mechanisms of adhesion formation and novel therapeutic approaches, while also improving the surgical consent process.
腹腔粘连与术后并发症增加、成本上升及工作量加大相关。我们进行了一项带有统计合并的系统评价,以估计接受腹部手术患者术后粘连的形成率、分布及严重程度。对1990年1月至2011年7月间所有报道粘连发生率、分布及严重程度的文章进行了文献检索。25篇文章符合纳入标准。腹部手术后粘连的加权平均形成率为54%(95%置信区间[CI] 40 - 68%),胃肠手术后为66%(95% CI 38 - 94%),妇产科手术后为51%(95% CI 40 - 63%),泌尿外科手术后为22%(95% CI 7 - 38%)。根据手术腹腔镜研究组分类,平均总体严重程度评分为1.11±0.98。腹腔镜手术使胃肠手术的粘连形成率降低了25%,并降低了粘连严重程度评分(腹腔镜手术;0.36±0.69对比开放手术;2.14±0.84)。我们的结果表明,腹腔粘连的发生率和严重程度在不同外科专业和手术之间存在差异。提高对粘连的认识有助于识别粘连形成的潜在机制和新的治疗方法,同时也能改善手术知情同意过程。