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一名人工瓣膜患者发生自发性双侧硬膜下血肿并与间日疟原虫疟疾相关:一例罕见病例报告。

Spontaneous bilateral subdural hematoma in a patient with a prosthetic valve and association with plasmodium vivax malaria: A rare case report.

作者信息

Abdi Ishak Ahmed, Sidow Nor Osman, Hassan Mohamed Sheikh, Yusuf Mohamud Mohamed Farah, Karataş Mesut

机构信息

Department of Cardiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia.

Department of Neurology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia.

出版信息

Ann Med Surg (Lond). 2022 Jul 13;80:104191. doi: 10.1016/j.amsu.2022.104191. eCollection 2022 Aug.

Abstract

INTRODUCTION AND IMPORTANCE

Bilateral subdural hematoma (SDH) is a very rare condition which can occur without any apparent etiology. It's characterized by a lower frequency of focal neurological impairments, which could delay the diagnosis and postpone treatment. The reported incidence of an acute spontaneous subdural hematoma (SSH) varies between 2% and 6.7% of all acute SDH. SDH following Plasmodium vivax (P. vivax) infection are uncommon to our knowledge, only two cases of SDH linked with P. vivax infection have been documented in the literature.

CASE PRESENTATION

We describe a case of a 31-year-old male with a history of mitral mechanical valve replacement on anti-coagulant presented with spontaneous bilateral subdural hematoma in the presence of malaria. The patient had a limited vague symptom, which delayed a prompt diagnosis of his disease.

CLINICAL DISCUSSION

Spontaneous subdural hematoma has only a few documented cases. Hypertension, infections, vascular malformations, ruptured aneurysms, thrombocytopenia caused by hematological and oncological illnesses, acquired or inherited types of coagulopathies, and drug abuse are all risk factors. Also, SDH has been documented in the literature as a consequence of Plasmodium infection. In addition to that this patient was on anti-epileptic medicines which might potentiate vitamin K antagonists. Numerous factors were thought to have contributed to this significant bleeding.

CONCLUSION

Patients on anticoagulants who exhibit nebulous symptoms, including a mild headache, should be subjected to a thorough history and examination. And any factor delaying an accurate diagnosis should be eliminated. This will complement the patient's plan and management.

摘要

引言与重要性

双侧硬膜下血肿(SDH)是一种非常罕见的病症,可在无任何明显病因的情况下发生。其特征是局灶性神经功能障碍的发生率较低,这可能会延迟诊断并推迟治疗。据报道,急性自发性硬膜下血肿(SSH)的发生率在所有急性SDH中为2%至6.7%。据我们所知,间日疟原虫(P. vivax)感染后发生的SDH并不常见,文献中仅记录了两例与间日疟原虫感染相关的SDH病例。

病例介绍

我们描述了一例31岁男性患者,有二尖瓣机械瓣膜置换史且正在接受抗凝治疗,在患疟疾的情况下出现自发性双侧硬膜下血肿。患者症状有限且模糊,这延迟了对其疾病的及时诊断。

临床讨论

自发性硬膜下血肿仅有少数文献记载的病例。高血压、感染、血管畸形、动脉瘤破裂、血液学和肿瘤性疾病引起的血小板减少、获得性或遗传性凝血障碍以及药物滥用都是危险因素。此外,文献中已将SDH记录为疟原虫感染的后果。除此之外,该患者正在服用抗癫痫药物,这可能会增强维生素K拮抗剂的作用。许多因素被认为促成了这次严重出血。

结论

正在接受抗凝治疗且出现包括轻度头痛在内的模糊症状的患者,应进行全面的病史询问和检查。应消除任何延迟准确诊断的因素。这将完善患者的治疗方案和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfa/9422195/f18e6e601976/gr1.jpg

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