原发性胰腺腺癌切除术后20年发生转移性肺腺癌：一例报告并文献复习
Metastatic pulmonary adenocarcinoma after 20 years of primary pancreatic adenocarcinoma resection: A case report and literature review.
作者信息
Dukmak Osama N, Zeer Almotazbellah, Sarhan Fajr M A, Al Mohtasib Mohammad Eid, Asbeh Yousef Abu
机构信息
Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Thoracic Department, Ahli Hospital, Hebron, Palestine.
出版信息
Ann Med Surg (Lond). 2022 Jul 13;80:104150. doi: 10.1016/j.amsu.2022.104150. eCollection 2022 Aug.
INTRODUCTION
Recurrency of Pancreatic adenocarcinoma after resection can be as high as 85%. Most of the recurrences happen within two years of pancreatic resection and may be local or present as a metastatic disease.
CLINICAL PRESENTATION
Herein, we report a patient who presented with metastatic pulmonary adenocarcinoma after 20 years of curative resection of pancreatic adenocarcinoma. Histopathology of the pulmonary mass confirms the diagnosis as a metastatic adenocarcinoma of gastrointestinal origin.
CONCLUSION
Despite the length of the disease-free period, lung metastasis of pancreatic cancer is the most likely diagnosis according to the clinical course, histopathology and biochemical tumor marker. Tumor marker Ca19-9 is very sensitive and reliable test to detect recurrency of pancreatic cancer even if the imaging modalities cannot detect the tumor.
引言
胰腺癌切除术后的复发率可高达85%。大多数复发发生在胰腺切除术后两年内，可能是局部复发或表现为转移性疾病。
临床表现
在此，我们报告一名患者，在胰腺癌根治性切除术后20年出现转移性肺腺癌。肺部肿块的组织病理学证实诊断为胃肠道来源的转移性腺癌。
结论
尽管无病生存期较长，但根据临床病程、组织病理学和生化肿瘤标志物，胰腺癌肺转移是最可能的诊断。肿瘤标志物Ca19-9是检测胰腺癌复发的非常敏感和可靠的检测方法，即使影像学检查无法检测到肿瘤。
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