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多发性骨髓瘤背景下起源于终丝的硬脊膜内浆细胞瘤：病例说明

Intradural plasmacytoma originating from the filum terminale in the setting of multiple myeloma: illustrative case.

作者信息

Glasser Jamieson, Glasser Ryan

机构信息

Florida State University College of Medicine, Sarasota, Florida; and.

Clinical Sciences, Florida State University College of Medicine, Sarasota, Florida.

出版信息

J Neurosurg Case Lessons. 2021 Feb 8;1(6):CASE20106. doi: 10.3171/CASE20106.

DOI:10.3171/CASE20106
PMID:36045934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9394177/
Abstract

BACKGROUND

Multiple myeloma (MM) has the propensity to spread to vertebral bodies; however, extramedullary plasmacytomas involving the central nervous system are extremely rare.

OBSERVATIONS

The authors report the first intradural extramedullary plasmacytoma in the lumbar region of the spine in a patient with preexisting MM. They present a 50-year-old female with severe back and radicular pain and progressive neurological deficit.

LESSONS

MM is typically treated with chemotherapy and radiation therapy. However, in this unique case, resection proved to be a key part of treatment.

摘要

背景

多发性骨髓瘤（MM）易于扩散至椎体；然而，累及中枢神经系统的髓外浆细胞瘤极为罕见。

观察结果

作者报告了首例发生于一名已有MM患者腰椎区域的硬脊膜内髓外浆细胞瘤。他们介绍了一名50岁女性，有严重的背部和神经根性疼痛以及进行性神经功能缺损。

经验教训

MM通常采用化疗和放疗进行治疗。然而，在这个独特的病例中，手术切除被证明是治疗的关键部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/9df78422737b/CASE20106f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/d7267bebad74/CASE20106f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/60a42d27acc1/CASE20106f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/52bf8af72b96/CASE20106f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/96f23a59ddb5/CASE20106f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/9df78422737b/CASE20106f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/d7267bebad74/CASE20106f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/60a42d27acc1/CASE20106f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/52bf8af72b96/CASE20106f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/96f23a59ddb5/CASE20106f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a3/9394177/9df78422737b/CASE20106f5.jpg

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J Med Case Rep. 2020 Oct 16;14(1):189. doi: 10.1186/s13256-020-02496-5.
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J Craniovertebr Junction Spine. 2019 Jul-Sep;10(3):192-196. doi: 10.4103/jcvjs.JCVJS_51_19.
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Extramedullary disease in multiple myeloma - controversies and future directions.
多发性骨髓瘤中的髓外疾病——争议与未来方向。
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