工程化磷树枝状大分子作为用于基因递送的强大非病毒纳米平台：癌症治疗未来的巨大希望。

Engineered phosphorus dendrimers as powerful non-viral nanoplatforms for gene delivery: a great hope for the future of cancer therapeutics.

作者信息

Mignani Serge, Shi Xiangyang, Bryszewska Maria, Shcharbin Dzmitry, Majoral Jean-Pierre

机构信息

Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006 Paris, France.

CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.

出版信息

Explor Target Antitumor Ther. 2022;3(1):50-61. doi: 10.37349/etat.2022.00071. Epub 2022 Feb 25.

During the past two decades, tremendous progress has been made in the dendrimer-based delivery of therapeutic molecules including, for instance, small molecules, macromolecules, and genes. This review deals with recent successes in the development of promising biocompatible phosphorus dendrimers, a specific type of dendrimer, to deliver genes to treat cancers.