Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt.
Molecules. 2022 Mar 27;27(7):2165. doi: 10.3390/molecules27072165.
Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.
乳腺癌（BrCa）是女性中最常见的恶性肿瘤，也是癌症死亡的第二大主要原因。BrCa 是最难治疗的恶性肿瘤之一，它导致了很大比例的癌症相关死亡。需要更有效的 BrCa 治疗的病例数量急剧增加。科学家正在寻找更有效的药物，如有机化合物，用于 BrCa 的预防和治疗，因为大多数化疗药物与癌症转移、药物耐药性和副作用有关。生物体内产生的天然化合物可促进细胞凋亡并抑制转移，从而减缓癌症的扩散。因此，这些化合物可能会延迟 BrCa 的扩散，提高生存率并降低由 BrCa 引起的死亡人数。一些天然化合物可抑制 BrCa 的产生，同时降低癌细胞的增殖并触发细胞死亡。天然化合物除了治疗方法外，还是治疗 BrCa 的有效且有潜力的药物。本文综述了在各种研究中证明具有 BrCa 细胞抗癌特性的天然化合物。对生物抗 BrCa 制剂的未来研究可能为 BrCa 治疗的新时代铺平道路，天然抗 BrCa 药物在提高 BrCa 患者生存率方面发挥着关键作用。
