Sun Guo-Zhe, Guo Liang, Wang Jun, Ye Ning, Wang Xun-Zhang, Sun Ying-Xian
Department of Cardiovascular Medicine, The First Hospital of China Medical University, 155 Nanjing Street, Heping, Shenyang, Liaoning, 110001, China.
Heart Institute, Cedars Sinai Medical Center, Los Angeles, 90048, CA, USA.
BMC Cardiovasc Disord. 2015 Sep 1;15:98. doi: 10.1186/s12872-015-0089-y.
To explore the association between atrial fibrillation (AF) and serum uric acid (SUA) in a general population in rural China.
From January 2013 to August 2013, we performed a cross-sectional study involving 11,956 permanent residents ≥ 35 years old in the rural Liaoning province of China. All participants completed a questionnaire, had a physical examination, and underwent an electrocardiogram (ECG) and echocardiogram. AF was diagnosed from ECG findings and/or a history of physician-confirmed AF. Blood samples were drawn for laboratory analyses and hyperuricemia was defined as an SUA level > 7.0 mg/dL in men and > 5.7 mg/dL in women, based on the NHANES-III laboratory definition. Logistic regression analyses were performed to estimate the crude and independent associations between hyperuricemia and the prevalence of AF.
A total of 139 participants were diagnosed with AF, of which, 72 were self-reported, 45 were ECG-diagnosed, and 22 were both. There was a higher prevalence of AF in participants with hyperuricemia than those with normal SUA levels (2.4 vs. 1.0 %; P < 0.001). The odds ratios (OR) and 95 % confidence intervals (CI) were 2.37 (1.61-3.49) when compared to participants with normal SUA. After adjustment for other cardiovascular and AF risk factors, the independent association remained (OR = 1.94, 95 % CI: 1.26-3.00). Similar associations were observed between SUA as a continuous variable and AF prevalence (adjusted OR = 1.20, 95 % CI: 1.06-1.36). The independent associations were significant in men (Ps < 0.05) but not in women (Ps > 0.05), although the interaction logistic regression analyses presented these differences as not being statistically significant (Ps > 0.05).
SUA is positively associated with the prevalence of AF in rural China.
探讨中国农村普通人群中心房颤动（AF）与血清尿酸（SUA）之间的关联。
2013年1月至2013年8月，我们在中国辽宁省农村地区对11956名年龄≥35岁的常住人口进行了一项横断面研究。所有参与者均完成问卷调查、体格检查，并接受心电图（ECG）和超声心动图检查。根据心电图检查结果和/或医生确诊的房颤病史诊断房颤。采集血样进行实验室分析，根据美国国家健康和营养检查调查（NHANES-III）实验室定义，男性高尿酸血症定义为SUA水平>7.0mg/dL，女性>5.7mg/dL。进行逻辑回归分析以估计高尿酸血症与房颤患病率之间的粗略和独立关联。
共有139名参与者被诊断为房颤，其中72名是自我报告的，45名是心电图诊断的，22名两者均有。高尿酸血症参与者的房颤患病率高于SUA水平正常者（2.4%对1.0%；P<0.001）。与SUA水平正常的参与者相比，比值比（OR）和95%置信区间（CI）为2.37（1.61-3.49）。在调整其他心血管和房颤危险因素后，独立关联仍然存在（OR=1.94，95%CI：1.26-3.00）。作为连续变量的SUA与房颤患病率之间也观察到类似的关联（调整后的OR=1.20，95%CI：1.06-1.36）。尽管交互逻辑回归分析显示这些差异无统计学意义（P>0.05），但独立关联在男性中显著（P<0.05），在女性中不显著（P>0.05）。
在中国农村，SUA与房颤患病率呈正相关。
