Zhang Yujie, Zhao Yuanru, Zhang Yuanyuan, Liu Qingguang, Zhang Mingzhen, Tu Kangsheng
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Front Pharmacol. 2022 Aug 15;13:961725. doi: 10.3389/fphar.2022.961725. eCollection 2022.
As a noninvasive treatment approach for cancer and other diseases, sonodynamic therapy (SDT) has attracted extensive attention due to the deep penetration of ultrasound, good focusing, and selective irradiation sites. However, intrinsic limitations of traditional sonosensitizers hinder the widespread application of SDT. With the development of nanotechnology, nanoparticles as sonosensitizers or as a vehicle to deliver sonosensitizers have been designed and used to target tissues or tumor cells with high specificity and accuracy. Autophagy is a common metabolic alteration in both normal cells and tumor cells. When autophagy happens, a double-membrane autophagosome with sequestrated intracellular components is delivered and fused with lysosomes for degradation. Recycling these cell materials can promote survival under a variety of stress conditions. Numerous studies have revealed that both apoptosis and autophagy occur after SDT. This review summarizes recent progress in autophagy activation by SDT through multiple mechanisms in tumor therapies, drug resistance, and lipid catabolism. A promising tumor therapy, which combines SDT with autophagy inhibition using a nanoparticle delivering system, is presented and investigated.
作为一种用于癌症和其他疾病的非侵入性治疗方法，声动力疗法（SDT）因其超声的深穿透性、良好的聚焦性和选择性照射部位而受到广泛关注。然而，传统声敏剂的固有局限性阻碍了SDT的广泛应用。随着纳米技术的发展，作为声敏剂或作为递送声敏剂载体的纳米颗粒已被设计并用于以高特异性和准确性靶向组织或肿瘤细胞。自噬是正常细胞和肿瘤细胞中常见的代谢改变。当自噬发生时，一个包裹着细胞内成分的双膜自噬体被转运并与溶酶体融合以进行降解。回收这些细胞物质可以在各种应激条件下促进细胞存活。大量研究表明，SDT后凋亡和自噬都会发生。本综述总结了SDT在肿瘤治疗、耐药性和脂质分解代谢中通过多种机制激活自噬的最新进展。提出并研究了一种有前景的肿瘤治疗方法，即使用纳米颗粒递送系统将SDT与自噬抑制相结合。
