Sun Xueshan, Zhen Xuemei, Liu Kaijie, Yang Wenqianzi, Gu Shuyan, Zhang Xu, Dong Hengjin
School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shannxi, China.
School of Health Care Management, Shandong University, 44 Wenhuaxi Rd, Jinan, Shandong, China.
BMC Musculoskelet Disord. 2025 Mar 5;26(1):220. doi: 10.1186/s12891-025-08432-2.
To estimate the health-related quality of life (HRQoL) of knee osteoarthritis outpatients in China overall and by body mass index (BMI), and to explore the factors associated with knee osteoarthritis.
This was a cross-sectional study in which outpatients with knee osteoarthritis were recruited from three tertiary hospitals in China from June 2020 to May 2021. The EuroQoL five-dimensional instrument was used to measure HRQoL. Descriptive analysis, one-way analysis of variance, and a Tobit regression model were performed.
One thousand and eight questionnaires were distributed, and nine hundred and fifty-two participants were included. The mean age was 61.71 years, and 61.03% of the participants were female. The mean health utility was 0.751 (95% CI 0.737, 0.765). The health utility varied significantly according to BMI: underweight = 0.627 (95% CI 0.536, 0.719), normal = 0.764 (95% CI 0.744, 0.784), overweight = 0.755 (95% CI 0.733, 0.776), and obese = 0.728 (95%CI 0.681, 0.776). Additionally, outpatients with knee osteoarthritis who were younger, had received treatment in the past six months, and had a disease duration shorter than 2 years had significantly higher HRQoL scores.
The HRQoL of knee osteoarthritis outpatients was considerably impaired and was significantly associated with BMI. These findings emphasize the importance of weight examination and management in outpatients with knee osteoarthritis for healthcare providers. Supplementary data were provided for public health-related policies and health economics studies, contributing to the development of effective management strategies and increasing the breadth of knowledge of HRQoL in outpatients with knee osteoarthritis.
总体及按体重指数（BMI）评估中国膝关节骨关节炎门诊患者的健康相关生活质量（HRQoL），并探讨与膝关节骨关节炎相关的因素。
这是一项横断面研究，于2020年6月至2021年5月在中国的三家三级医院招募膝关节骨关节炎门诊患者。采用欧洲五维健康量表来测量HRQoL。进行了描述性分析、单因素方差分析和Tobit回归模型分析。
共发放1008份问卷，纳入952名参与者。平均年龄为61.71岁，61.03%的参与者为女性。平均健康效用值为0.751（95%置信区间0.737, 0.765）。健康效用值根据BMI有显著差异：体重过轻=0.627（95%置信区间0.536, 0.719），正常=0.764（95%置信区间0.744, 0.784），超重=0.755（95%置信区间0.733, 0.776），肥胖=0.728（95%置信区间0.681, 0.776）。此外，年龄较小、在过去六个月内接受过治疗且病程短于2年的膝关节骨关节炎门诊患者的HRQoL得分显著更高。
膝关节骨关节炎门诊患者的HRQoL受到相当程度的损害，且与BMI显著相关。这些发现强调了医疗服务提供者对膝关节骨关节炎门诊患者进行体重检查和管理的重要性。为公共卫生相关政策和健康经济学研究提供了补充数据，有助于制定有效的管理策略，并增加对膝关节骨关节炎门诊患者HRQoL的认识广度。
