抑郁症临床亚型中的血小板单胺氧化酶活性与地塞米松抑制试验抑制情况

Platelet MAO activity in clinical subtypes of depression and DST suppression.

作者信息

Poirier M F, Lôo H, Mitrani N, Benkelfat C, Askienazy S, Le Fur G

出版信息

Acta Psychiatr Scand. 1987 May;75(5):456-63. doi: 10.1111/j.1600-0447.1987.tb02818.x.

DOI:10.1111/j.1600-0447.1987.tb02818.x

Abstract

Platelet MAO activity was measured in 75 hospitalized depressed patients and in 31 healthy subjects. Plasmas post dexamethasone cortisol levels were examined in 73 patients. Results indicate that higher platelet MAO activity does not occur in all, but only in male major depressed patients. No relationship between changes of MAO activity and specific clinical subtypes was found. Platelet MAO activity is not different between DST suppressors and DST non suppressors. The authors suggest that platelet MAO activity may be related to non specific factors such as sex, age, but not to diagnosis of depression.

摘要

对75名住院抑郁症患者和31名健康受试者进行了血小板单胺氧化酶（MAO）活性测定。对73名患者检测了地塞米松后血浆皮质醇水平。结果表明，并非所有抑郁症患者血小板MAO活性都升高，仅男性重度抑郁症患者出现这种情况。未发现MAO活性变化与特定临床亚型之间存在关联。地塞米松抑制试验（DST）抑制者与非抑制者的血小板MAO活性无差异。作者认为，血小板MAO活性可能与性别、年龄等非特异性因素有关，而与抑郁症诊断无关。