九元 N,N,O-杂环的构建 Pd 催化的[6+3]偶极环加成反应
Construction of nine-membered N,N,O-heterocycles Pd-catalyzed [6+3] dipolar cycloaddition.
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, China.
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
出版信息
Chem Commun (Camb). 2022 Sep 20;58(75):10560-10563. doi: 10.1039/d2cc03666e.
A new approach for the synthesis of 9-membered N,N,O-heterocycles by Pd-catalyzed [6+3] dipolar cycloaddition of -iminoisoquinolinium ylides and 2-vinyl oxetanes has been developed. The scope of this cycloaddition was demonstrated with 28 examples. This is another important synthetic strategy for medium-sized rings by employing -iminoisoquinolinium ylides as ternary synthons.
发展了钯催化的 -亚氨基异喹啉鎓叶立德与 2-乙烯基氧杂环丁烷的[6+3]偶极环加成反应，用于合成 9 元 N,N,O-杂环的新方法。该环加成反应的范围已通过 28 个实例证明。这是使用 -亚氨基异喹啉鎓叶立德作为三元合成子合成中等环的另一个重要的合成策略。
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