CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, 20014 Donostia-San Sebastián, Spain.
CIC nanoGUNE, Basque Research and Technology Alliance (BRTA), 20018 Donostia-San Sebastián, Spain.
Nanoscale Horiz. 2022 Oct 24;7(11):1259-1278. doi: 10.1039/d2nh00276k.
Surface-enhanced infrared absorption (SEIRA) leads to a largely improved detection of polar molecules, compared to standard infrared absorption. The enhancement principle is based on localized surface plasmon resonances of the substrate, which match the frequency of molecular vibrations in the analyte of interest. Therefore, in practical terms, the SEIRA sensor needs to be tailored to each specific analyte. We review SEIRA sensors based on metal plasmonics for the detection of biomolecules such as DNA, proteins, and lipids. We further focus this review on chemical SEIRA sensors, with potential applications in quality control, as well as on the improvement in sensor geometry that led to the development of multiresonant SEIRA substrates as sensors for multiple analytes. Finally, we give an introduction into the integration of SEIRA sensors with surface-enhanced Raman scattering (SERS).
表面增强红外吸收（SEIRA）与标准红外吸收相比，大大提高了对极性分子的检测能力。增强原理基于基底的局域表面等离激元共振，与感兴趣的分析物中分子振动的频率相匹配。因此，实际上，SEIRA 传感器需要针对每个特定的分析物进行定制。我们综述了基于金属等离子体的 SEIRA 传感器在检测生物分子（如 DNA、蛋白质和脂质）方面的应用。我们进一步将重点放在化学 SEIRA 传感器上，这些传感器具有质量控制方面的潜在应用，以及传感器几何形状的改进，这导致了多共振 SEIRA 基底的发展，作为用于多种分析物的传感器。最后，我们介绍了 SEIRA 传感器与表面增强拉曼散射（SERS）的集成。
